Abstract
Pigment-Epitelium Derived Factor (PEDF) is a member of the family of the non-inhibitory serpins, distributed in almost all tissues, including CNS, where is largely expressed. Comparatively, PEDF has been described as highly active in the Central Nervous System (CNS) acting as antiangiogenic, anti-vasopermeability, neurotrophic and neuroprotector factor. Hypoxia is a pathological condition…