CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Medical degree from the University of São Paulo (2000), followed by a PhD (2010) and a postdoctoral fellowship (2016) in Endocrinology from the same institution.Attending physician at the Cancer Institute of the State of São Paulo (ICESP) and at the Thyroid Unit of the Endocrinology Department at Hospital das Clínicas, University of Sao Paulo Medical School (HCFMUSP). Researcher at the Laboratory of Cellular and Molecular Endocrinology (LIM-25) and collaborating professor at the University of São Paulo Medical School.Member of the Brazilian Society of Endocrinology and Metabology, the American Thyroid Association, and the Latin American Thyroid Society.Extensive experience in Endocrinology, with a focus on thyroid disorders, including hormonal dysfunctions, thyroid nodules, and thyroid cancer. (Source: Lattes Curriculum)
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Clinical follow-up of patients with papillary thyroid carcinoma (PTC) includes periodic dosage of serum thyroglobulin (Tg) and neck ultrasound. Patients submitted to partial thyroidectomies or not treated with I131 may have persistent Tg despite no tumor recurrence. In addition, the presence of anti-Tg may interfere in the dosage of Tg by immunometric assays, making it necessary to develo…
The Hürthle cell carcinoma is considered a variant of the follicular thyroid carcinoma, despite distinct clinical behavior. Genetic abnormalities associated to thyroid carcinogenesis have been studied, mainly in papillary and follicular carcinomas. A few gene mutations were identified in Hürthle cell carcinoma, involving mitochondrial genes, RAS e MEN1. However, they were restricted to a …
The oxidative stress is a dynamic condition characterized by the imbalance between oxidants and antioxidants. Firstly, reactive oxygen species (ROS), without the counteraction of antioxidants, promote DNA damage. However, antioxidants agents, such as NRF2 which activates cytoprotector genes, favor the survival of cancerigenous cells. Under basal conditions, the repressor protein KEAP1 bin…
The conventional treatment for papillary thyroid cancer (PTC) is total thyroidectomy, radioiodine therapy and TSH suppression. This is achieved by replacement of levothyroxine (T4) in supraphysiological doses. Since the biologically active thyroid hormone is T3, in the absence of thyroid production of this hormone, the availability of serum and intracellular T3 to inhibit TSH secretion de…
| 3 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 1 / 0 | Completed scholarships in Brazil |
| 5 / 4 | All research grants and scholarships |
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