Abstract
Prepulse inhibition (PPI) is the reduction in the startle response caused by a low intensity non-startling stimulus (prepulse) which is presented shortly before the startle stimulus and is an operational measure of sensorimotor gating. PPI is impaired in schizophrenia patients and can be induced in rats by systemic administration of N-methyl-D-aspartate (NMDA) glutamatergic antagonists su…