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Ana Marisa Chudzinski-Tavassi

CV Lattes


Secretaria da Saúde (São Paulo - Estado). Instituto Butantan  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Ana Marisa Chudzinski -Tavassi is a Scientific Research, Director of Innovation and Coordinator of the Center of Excellence in New Target Discovery at the Instituto Butantan, São Paulo. Graduated in Pharmacy and Biochemistry on the Federal University of Paraná (1982), Master degree on Biochemistry and Molecular Biology from Federal University of São Paulo (1989) and PhD at Biochemistry and Molecular Biology from the Federal University of São Paulo and Institut Pasteur-Paris (1993). Post-doc at Buenos Aires National Academy of Medicine, Argentine (2001). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: inhibitors, recombinant proteins, animal Identification and characterization of molecules from animal venoms and secretions, focusing on the identification of mechanisms of action, molecular targets, pre-clinical assays and scale up. From Lonomia obliqua venom several cytoprotective molecules were identified, and they are used on studies on cellular models related to immunoinflamatory and degenerative diseases. From a cDNA library of the salivary glands of the Amblyomma sculptun tick, a Kunitz inhibitor named Amblyomin-X was cloned and expressed as a recombinant protein which was characterized as an antitumor molecule in vitro and in in vivo assays. Pre-clinical assays were performed, and at the moment molecular targets are being identified and validated. (Source: Lattes Curriculum)

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Animal venoms as tools for the discovery of new molecular targets: Strategies developed by CENTD

Published by Agência FAPESP - February 12, 2019. The CENTD is a research center focused on the discovery of molecular targets and signaling pathways, implemented at the Butantan Institute, in São Paulo, Brazil, as a result of a typical triple helix collaborative partnership between FAPESP, GlaxoSmithKline (GSK) and Butantan Institute. In it, first-class science is being conducted employing the most modern molecular and cellular biology techniques, including phenotypic multi-parametric assays, interatomic, proteomic, transcriptomic analysis and bioinformatics. The CENTD aims to identify and validate new molecular targets related to immuno-inflammatory and degenerative diseases, like osteoarthritis and cancer, using venoms, toxins and peptides from the Brazilian biodiversity and from other countries. A Biobank was created for the maintenance and management of the venom collection. Pro and anti-inflammatory cell models, tumor cell cultures and tumor translational models were established with the aim of finding active molecules, targets and signaling pathways to allow for the development of innovative medicines. After identification of a potential new target, subsequent validation utilizes molecular biology methodologies like the CRISPR/Cas9 system for gene knockout and expression activation, knockout animals and in vitro and in vivo tests. To date, 19 whole venoms and 28 peptides have been screened for pro and anti-inflammatory effects in 6 cellular models that have been established and standardized, including osteoclasts, chondrocytes, synoviocytes, THP-1 monocyte/macrophage, adipocytes and neurons-like cells. Isolated fractions with potential anti-inflammatory and/or cytoprotective properties have been selected for further validation. In addition, cytoprotective peptides were tested in cell cultures from 10 patients with osteoarthritis (OA) to better understand the molecular mechanisms involved in disease and to find new molecular targets for OA treatment. Concerning cancer models, in addition to studies on tumor cell cultures, we performed transcriptomic studies on spontaneous melanoma tumors occurring in horses in the Butantan Institute`s Farm. Selected tumors were treated with Amblyomin-X, a recombinant Kunitz-type inhibitor derived from a cDNA library from the Amblyomma sculptun tick salivary glands. Amblyomin-X was previously described as a proteasome inhibitor inducing selective cell death in several tumor cells. This molecule promotes endoplasmic reticulum (ER) stress, mitochondrial dysfunction, cytochrome-c release, poly(ADP-ribose) polymerase (PARP) cleavage and activation of caspases in several tumor cell types. Results derived from the transcriptomic analysis of the horse tumor translational model indicate that this molecule triggers immunogenic cell death (ICD) by triggering key molecular pathways. As a general conclusion, the collaborative partnership established in the CENTD could be an effective model for the development of high impact SCIENCE in concert with novel drug discovery. Ana Marisa Chudzinski-Tavassi | FAPESP Week London.
Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (30)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications28
Citations153
Cit./Article5.5
Data from Web of Science

SATO, ANA CLAUDIA; BOSCH, ROSEMARY VIOLA; ALVES WILL, SONIA ELISABETE; ALVAREZ-FLORES, MIRYAM PAOLA; GOLDFEDER, MAURICIO BARBUGIANI; MESQUITA PASQUALOTO, KERLY FERNANDA; VAZ GALVAO DA SILVA, BRBARA ATHAYDE; DE ANDRADE, SONIA APARECIDA; CHUDZINSKI-TAVASSI, ANA MARISA. Exploring the in vivo wound healing effects of a recombinant hemolin from the caterpillar Lonomia obliqua. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 22, . Web of Science Citations: 1. (13/07467-1, 13/06892-0)

ALVAREZ-FLORES, MIRYAM PAOLA; FURLIN, DANIEL; RAMOS, OSCAR H. P.; BALAN, ANDREA; KONNO, KATSUHIRO; CHUDZINSKI-TAVASSI, ANA MARISA. Losac, the First Hemolin that Exhibits Procogulant Activity through Selective Factor X Proteolytic Activation. Journal of Biological Chemistry, v. 286, n. 9, p. 6918-6928, . Web of Science Citations: 9.

WAISMAM, KALINE; CHUDZINSKI-TAVASSI, ANA MARISA; CARRIJO-CARVALHO, LINDA C.; FERNANDES PACHECO, MARIO T.; FARSKY, SANDRA H. P.. Lopap: A non-inflammatory and cytoprotective molecule in neutrophils and endothelial cells. Toxicon, v. 53, n. 6, p. 652-659, . Web of Science Citations: 7.

MESQUITA PASQUALOTO, KERLY FERNANDA; CARRIJO-CARVALHO, LINDA CHRISTIAN; CHUDZINSKI-TAVASSI, ANA MARISA. Rational development of novel leads from animal secretion based on coagulation and cell targets: 1. In silico analysis to explore a peptide derivative as lipocalins' signature. Toxicon, v. 69, n. SI, p. 200-210, . Web of Science Citations: 0.

LOURENCO OLIVEIRA, DANIELLA GORETE; ALVAREZ-FLORES, MIRYAM PAOLA; LOPES, ADRIANA RIOS; CHUDZINSKI-TAVASSI, ANA MARISA. Functional characterisation of Vizottin, the first factor Xa inhibitor purified from the leech Haementeria vizottoi. THROMBOSIS AND HAEMOSTASIS, v. 108, n. 3, p. 570-578, . Web of Science Citations: 4. (98/14307-9)

DREWES, C. C.; DIAS, R. Y. S.; HEBEDA, C. B.; SIMONS, S. M.; BARRETO, S. A.; FERREIRA JUNIOR, J. M.; CHUDZINSKI-TAVASSI, A. M.; FARSKY, S. H. P.. Actions of the Kunitz-type serine protease inhibitor Amblyomin-X on VEGF-A-induced angiogenesis. Toxicon, v. 60, n. 3, p. 333-340, . Web of Science Citations: 15.

MORAIS, KATIA L. P.; MESQUITA PASQUALOTO, KERLY FERNANDA; FERNANDES PACHECO, MARIO THIEGO; BERRA, CAROLINA MARIA; ALVAREZ-FLORES, MIRYAM PAOLA; CHUDZINSKI-TAVASSI, ANA MARISA. Rational development of a novel TFPI-like inhibitor from Amblyomma cajennense tick. Toxin Reviews, v. 33, n. 1-2, SI, p. 48-52, . Web of Science Citations: 3. (11/05969-4, 10/07958-7)

DE SOUZA CARVALHO, F. R.; CARRIJO-CARVALHO, L. C.; CHUDZINSKI-TAVASSI, A. M.; FORONDA, A. S.; DE FREITAS, D.. Serine-like proteolytic enzymes correlated with differential pathogenicity in patients with acute Acanthamoeba keratitis. Clinical Microbiology and Infection, v. 17, n. 4, p. 603-609, . Web of Science Citations: 8.

CARRIJO-CARVALHO‚ L.C.; CHUDZINSKI-TAVASSI‚ A.M.. The venom of the Lonomia caterpillar: An overview. Toxicon, v. 49, n. 6, p. 741-757, .

MARIA, DURVANEI AUGUSTO; DE SOUZA, JEAN GABRIEL; MORAIS, KATIA L. P.; BERRA, CAROLINA MARIA; ZAMPOLLI, HAMILTON DE CAMPOS; DEMASI, MARILENE; SIMONS, SIMONE MICHAELA; SAITO, RENATA DE FREITAS; CHAMMAS, ROGER; CHUDZINSKI-TAVASSI, ANA MARISA. A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production. INVESTIGATIONAL NEW DRUGS, v. 31, n. 3, p. 493-505, . Web of Science Citations: 26. (98/14307-9)

ANDRADE, S. A.; CARRIJO-CARVALHO, L. C.; PECEGUINI, L. A. M.; WLIAN, L.; SATO, A. C.; LUCHIARI, C.; SILVA, E. D.; MAFFEI, F. H. A.; CHUDZINSKI-TAVASSI, A. M.. Reversal of the anticoagulant and anti-hemostatic effect of low molecular weight heparin by direct prothrombin activation. Brazilian Journal of Medical and Biological Research, v. 45, n. 10, p. 929-934, . Web of Science Citations: 2.

BUFALO, MICHELLE C.; ALMEIDA, MAIRA E.; FRANCA, ISABELLA ARAUJO; ZAMBELLI, VANESSA O.; SANT'ANNA, MORENA BRAZIL MARTINS; KIMURA, LOUISE F.; GIARDINI, ALINE CAROLINA; CURY, YARA; SAMPAIO, SANDRA COCCUZZO. Advanced glycation endproducts produced by in vitro glycation of type I collagen modulate the functional and secretory behavior of dorsal root ganglion cells cultivated in two-dimensional system. Experimental Cell Research, v. 382, n. 2-3, . Web of Science Citations: 0. (16/12128-0, 15/50040-4, 12/51241-5, 16/10886-4)

ALVAREZ-FLORES, MILYAM P.; HEBERT, AUDREY; GOUELLE, CATHY; GELLER, SARAH; CHUDZINSKI-TAVASSI, ANA M.; PELLERIN, LUC. Neuroprotective effect of rLosac on supplement-deprived mouse cultured cortical neurons involves maintenance of monocarboxylate transporter MCT2 protein levels. Journal of Neurochemistry, v. 148, n. 1, p. 80-96, . Web of Science Citations: 1. (13/07467-1, 15/50040-4)

BATISTA‚ I.F.C.; CHUDZINSKI-TAVASSI‚ A.M.; FARIA‚ F.; SIMONS‚ S.M.; BARROS-BATESTTI‚ D.M.; LABRUNA‚ M.B.; LEÃO‚ L.I.; HO‚ P.L.; JUNQUEIRA-DE-AZEVEDO‚ I.L.M.. Expressed sequence tags (ESTs) from the salivary glands of the tick Amblyomma cajennense(Acari: Ixodidae). Toxicon, v. 51, n. 5, p. 823-834, .

CHUDZINSKI-TAVASSI, ANA MARISA; MORAIS, KATIA L. P.; FERNANDES PACHECO, MARIO THIEGO; MESQUITA PASQUALOTO, KERLY FERNANDA; DE SOUZA, JEAN GABRIEL. Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates. BIOMEDICINE & PHARMACOTHERAPY, v. 77, p. 14-19, . Web of Science Citations: 8. (13/07467-1, 10/07958-7, 98/14307-9, 11/05969-4)

PACHECO, MARIO T. F.; MORAIS, KATIA L. P.; BERRA, CAROLINA M.; DEMASI, MARILENE; SCIANI, JULIANA M.; BRANCO, VANIA G.; BOSCH, ROSEMARY V.; IQBAL, ASIF; CHUDZINSKI-TAVASSI, ANA MARISA. Specific role of cytoplasmic dynein in the mechanism of action of an antitumor molecule, Amblyomin-X. Experimental Cell Research, v. 340, n. 2, p. 248-258, . Web of Science Citations: 7. (13/07467-1, 10/07958-7, 11/05969-4)

DREWES, C. C.; DIAS, R. Y.; BRANCO, V. G.; CAVALCANTE, M. F.; SOUZA, J. G.; ABDALLA, D. S. P.; CHUDZINSKI-TAVASSI, A. M.; FARSKY, S. H. P.. Post-transcriptional control of Amblyomin-X on secretion of vascular endothelial growth factor and expression of adhesion molecules in endothelial cells. Toxicon, v. 101, p. 1-10, . Web of Science Citations: 7. (10/19802-1, 12/06944-8, 13/07467-1, 09/08584-6)

DE SOUZA, JEAN GABRIEL; MORAIS, KATIA L. P.; ANGLES-CANO, EDUARDO; BOUFLEUR, PAMELA; DE MELLO, EVANDRO SOBROZA; MARIA, DURVANEI AUGUSTO; TAEMI ORIGASSA, CLARICE SILVIA; ZAMPOLLI, HAMILTON DE CAMPOS; SARAIVA CAMARA, NIELS OLSEN; BERRA, CAROLINA MARIA; et al. Promising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma model. ONCOTARGET, v. 7, n. 38, p. 62255-62266, . Web of Science Citations: 6. (12/02270-2, 12/06944-8, 10/07958-7, 15/50040-4, 13/07467-1)

PACHECO, MARIO T. F.; BERRA, CAROLINA M.; MORAIS, KATIA L. P.; SCIANI, JULIANA M.; BRANCO, VANIA G.; BOSCH, ROSEMARY V.; CHUDZINSKI-TAVASSI, ANA M.. Dynein Function and Protein Clearance Changes in Tumor Cells Induced by a Kunitz-Type Molecule, Amblyomin-X. PLoS One, v. 9, n. 12, . Web of Science Citations: 13. (13/07467-1, 11/05969-4, 98/14307-9)

BOSCH, ROSEMARY VIOLA; ALVAREZ-FLORES, MIRYAM PAOLA; MARIA, DURVANEI AUGUSTO; CHUDZINSKI-TAVASSI, ANA MARISA. Hemolin triggers cell survival on fibroblasts in response to serum deprivation by inhibition of apoptosis. BIOMEDICINE & PHARMACOTHERAPY, v. 82, p. 537-546, . Web of Science Citations: 5. (13/06892-0, 15/50040-4, 13/07467-1)

BRANCO, VANIA G.; IQBAL, ASIF; ALVAREZ-FLORES, MIRYAM P.; SCIANI, JULIANA M.; DE ANDRADE, SONIA A.; IWAI, LEO K.; SERRANO, SOLANGE M. T.; CHUDZINSKI-TAVASSI, ANA M.. Amblyomin-X having a Kunitz-type homologous domain, is a noncompetitive inhibitor of FXa and induces anticoagulation in vitro and in vivo. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1864, n. 10, p. 1428-1435, . Web of Science Citations: 6. (13/07467-1, 15/50040-4)

KERKIS, IRINA; DE BRANDO PRIETO DA SILVA, ALVARO ROSSAN; POMPEIA, CELINE; TYTGAT, JAN; DE SA JUNIOR, PAULO L.. Toxin bioportides: exploring toxin biological activity and multifunctionality. CELLULAR AND MOLECULAR LIFE SCIENCES, v. 74, n. 4, p. 647-661, . Web of Science Citations: 4. (15/50040-4)

IQBAL, ASIF; GOLDFEDER, MAURICIO BARBUGIANI; MARQUES-PORTO, RAFAEL; ASIF, HUMA; DE SOUZA, JEAN GABRIEL; FARIA, FERNANDA; CHUDZINSKI-TAVASSI, ANA MARISA. Revisiting antithrombotic therapeutics; sculptin, a novel specific, competitive, reversible, scissile and tight binding inhibitor of thrombin. SCIENTIFIC REPORTS, v. 7, . Web of Science Citations: 2. (13/07467-1, 15/50040-4)

MAMBELLI-LISBOA, NICOLE CAROLINE; SCIANI, JULIANA MOZER; BRANDAO PRIETO DA SILVA, ALVARO ROSSAN; KERKIS, IRINA. Co-Localization of Crotamine with Internal Membranes and Accentuated Accumulation in Tumor Cells. Molecules, v. 23, n. 4, . Web of Science Citations: 1. (15/50040-4)

MORAIS, KATIA L. P.; FERNANDES PACHECO, MARIO THIEGO; BERRA, CAROLINA MARIA; BOSCH, ROSEMARY V.; SCIANI, JULIANA MOZER; CHAMMAS, ROGER; SAITO, RENATA DE FREITAS; IQBAL, ASIF; CHUDZINSKI-TAVASSI, ANA MARISA. Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell. Molecular and Cellular Biochemistry, v. 415, n. 1-2, p. 119-131, . Web of Science Citations: 7. (13/07467-1, 10/07958-7, 98/14307-9, 11/05969-4)

MESQUITA PASQUALOTO, KERLY FERNANDA; BALAN, ANDREA; BARRETO, SANDRA ALVES; SIMONS, SIMONE MICHAELA; CHUDZINSKI-TAVASSI, ANA MARISA. Structural Findings and Molecular Modeling Approach of a TFPI-Like Inhibitor. PROTEIN AND PEPTIDE LETTERS, v. 21, n. 5, p. 452-457, . Web of Science Citations: 6.

XAVIER PRADO AMORIM, ADRIANE MICHELE; DE OLIVEIRA, URSULA CASTRO; FARIA, FERNANDA; MESQUITA PASQUALOTO, KERLY FEMANDA; JUNQUEIRA-DE-AZEVEDO, INACIO DE L. M.; CHUDZINSKI-TAVASSI, ANA MARISA. Transcripts involved in hemostasis: Exploring salivary complexes from Haementeria vizottoi leeches through transcriptomics, phylogenetic studies and structural features. Toxicon, v. 106, p. 20-29, . Web of Science Citations: 4. (11/16393-6)

PAVON, LORENA FAVARO; CAPPER, DAVID; SIBOV, TATIANA TAIS; CAMINADA DE TOLEDO, SILVIA REGINA; THOMALE, ULRICH-W.; DE SOUZA, JEAN GABRIEL; CABRAL, FRANCISCO ROMERO; BERRA, CAROLINA MARIA; SILVA DA COSTA, MARCOS DEVANIR; NICACIO, JARDEL MENDONCA; et al. New therapeutic target for pediatric anaplastic ependymoma control: study of anti-tumor activity by a Kunitz-type molecule, Amblyomin-X. SCIENTIFIC REPORTS, v. 9, . Web of Science Citations: 0. (12/06944-8)

VILLAS-BOAS, ISADORA MARIA; BONFA, GIULIANO; TAMBOURGI, DENISE V.. Venomous caterpillars: From inoculation apparatus to venom composition and envenomation. Toxicon, v. 153, p. 39-52, . Web of Science Citations: 1. (17/07009-4, 15/50040-4, 13/50158-0)

TEIXEIRA, CATARINA; FERNANDES, CRISTINA MARIA; LEIGUEZ, ELBIO; CHUDZINSKI-TAVASSI, ANA MARISA. Inflammation Induced by Platelet-Activating Viperid Snake Venoms: Perspectives on Thromboinflammation. FRONTIERS IN IMMUNOLOGY, v. 10, . Web of Science Citations: 0. (15/24701-3, 15/50040-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Maria Esther Ricci da. Análise proteômica do complexo salivar da sanguessuga Haementeria depressa. 2004. 138f. Tese (Doutorado) – Programa de Pós-graduação Interunidades em Biotecnologia. Universidade de São Paulo (USP). São Paulo. (99/12087-4)

Patent applications

PEPTÍDEO ISOLADO E SEU USO, COMPOSIÇÃO FARMACÊUTICA, MÉTODO PARA REDUZIR MORTE CELULAR E DEGENERAÇÃO TECIDUAL, MÉTODO PARA REGENERAÇÃO TECIDUAL EM UM ALVO E MÉTODO PARA CURAR FERIMENTO PI0907469-4 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi - January 2009, 22

PROCESSO DE PURIFICAÇÃO DE PROTEÍNAS SOLÚVEIS DAS CERDAS DA L. OBLÍQUA COM ATIVIDADE ATIVADORA DE PROTROMBINA; PROCESSO PARA DETERMINAÇÃO PARCIAL DA SEQUÊNCIA DE AMINOÁCIDOS DO ATIVADOR DE PROTROMBINA; PROCESSO DE DETERMINAÇÃO DA ATIVIDADE ATIVADORA DE PROTROMBINA DA FRAÇÃO II, SEQUÊNCIA N-TERMINAL E SEQUÊNCIA DE FRAGMENTOS INTERNOS DA FRAÇÃO ATIVADORA DE PROTROMBINA, ATIVADOR DE PROTROMBINA E USO DO ATIVADOR DE PROTROMBINA PI0200269-8 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Cleyson Valença Reis - January 2002, 31

PURIFICATION AND CHARACTERIZATION OF A PROTHROMBIN ACTIVATOR FROM THE BRISTLED OF LONOMIA OBLIQUA CA2471410 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Chudzinski-Tavassi; Cleyson Reis - January 2003, 29

LOPAP-BASED PHARMACEUTICAL COMPOSITIONS AND USES THEREOF CA2577915 - Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Cleyson Valença Reis; Paulo Lee Ho; Celso Raul Romero Ramos ; Sandra Helena Poliselli Farsky; Márcio Fritzen - September 2006, 08

KUNITZ-TYPE RECOMBINANT INHIBITOR CA2581001 - Ana Marisa Chudzinski-Tavassi; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); União Química Farmacêutica Nacional S/A. Ana Marisa Chudzinski-Tavassi; Durvanei Augusto Maria; Isabel de Fátima Correia Batista; Paulo Lee Ho - March 2008, 14

METHODS FOR GROWING TISSUE WITH LOPAP-BASED PHARMACEUTICAL COMPOSITIONS CA2621482 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Márcio Falci; Durvanei Augusto Maria; Cleyson Valença Reis - September 2006, 08

KUNITZ-TYPE RECOMBINANT INHIBITOR CA2680759 - Ana Marisa Chudzinski-Tavassi; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); União Química Farmacêutica Nacional S/A. Ana Marisa Chudzinski-Tavassi; Durvanei Augusto Maria; Isabel de Fátima Correia Batista; Paulo Lee Ho - March 2008, 14

PEPTIDES, COMPOSITIONS, AND USES THEREOF CA2712807 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Janaina de Souza Ventura; Linda Christian Carrijo Carvalho - January 2009, 22

KUNITZ-TYPE RECOMBINANT INHIBITOR CN200580038992 - Ana Marisa Chudzinski-Tavassi; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); União Química Farmacêutica Nacional S/A. Ana Marisa Chudzinski-Tavassi; Durvanei Augusto Maria; Isabel de Fátima Correia Batista; Paulo Lee Ho - March 2008, 14

METHODS FOR GROWING TISSUE WITH LOPAP-BASED PHARMACEUTICAL COMPOSITIONS CN200680040955 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Márcio Falci; Durvanei Augusto Maria; Cleyson Valença Reis - September 2006, 08

PEPTIDES, COMPOSITIONS, AND USES THEREOF CN200980108018 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Janaina de Souza Ventura; Linda Christian Carrijo Carvalho - January 2009, 22

PURIFICATION AND CHARACTERIZATION OF A PROTHROMBIN ACTIVATOR FROM THE BRISTLED OF LONOMIA OBLIQUA EP20030706143 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Chudzinski-Tavassi; Cleyson Reis - January 2003, 29

LOPAP-BASED PHARMACEUTICAL COMPOSITIONS AND USES THEREOF EP20050774298 - Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Cleyson Valença Reis; Paulo Lee Ho; Celso Raul Romero Ramos ; Sandra Helena Poliselli Farsky; Márcio Fritzen - September 2006, 08

KUNITZ-TYPE RECOMBINANT INHIBITOR EP20050782904 - Ana Marisa Chudzinski-Tavassi; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); União Química Farmacêutica Nacional S/A. Ana Marisa Chudzinski-Tavassi; Durvanei Augusto Maria; Isabel de Fátima Correia Batista; Paulo Lee Ho - September 2005, 15

METHODS FOR GROWING TISSUE WITH LOPAP-BASED PHARMACEUTICAL COMPOSITIONS EP20060775034 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Márcio Falci; Durvanei Augusto Maria; Cleyson Valença Reis - September 2006, 08

KUNITZ-TYPE RECOMBINANT INHIBITOR EP20080733487 - Ana Marisa Chudzinski-Tavassi; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); União Química Farmacêutica Nacional S/A. Ana Marisa Chudzinski-Tavassi; Durvanei Augusto Maria; Isabel de Fátima Correia Batista; Paulo Lee Ho - March 2008, 14

PEPTIDES, COMPOSITIONS, AND USES THEREOF EP20090704223 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Janaina de Souza Ventura; Linda Christian Carrijo Carvalho - January 2009, 22

INHIBIDOR RECOMBINANTE DE TIPO KUNITZ ES2410160 - Ana Marisa Chudzinski-Tavassi; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); União Química Farmacêutica Nacional S/A. Ana Marisa Chudzinski-Tavassi; Durvanei Augusto Maria; Isabel de Fátima Correia Batista; Paulo Lee Ho - September 2005, 15

PÉPTIDOS, COMPOSICIONES, Y SUS USOS ES2559195 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Janaina de Souza Ventura; Linda Christian Carrijo Carvalho - January 2009, 22

PEPTIDES, COMPOSITIONS, AND USES THEREOF IL207174 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Janaina de Souza Ventura; Linda Christian Carrijo Carvalho - January 2009, 22

PEPTIDES, COMPOSITIONS, AND USES THEREOF JP2011510060 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Janaina de Souza Ventura; Linda Christian Carrijo Carvalho - January 2009, 22

PURIFICATION AND CHARACTERIZATION OF A PROTHROMBIN ACTIVATOR FROM THE BRISTLED OF LONOMIA OBLIQUA PCT/BR2003/000012 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Chudzinski-Tavassi; Cleyson Reis - January 2003, 29

PROCESS FOR OBTAINING RECOMBINANT PROTHROMBIN ACTIVATING PROTEASE (RLOPAP) IN MONOMERIC FORM; THE RECOMBINANT PROTHROMBIN ACTIVATING PROTEASE (RLOPAP) AS WELL AS ITS AMINO ACID SEQUENCE; THE USE OF THIS PROTEASE AS A DEFIBRINOGENASE AGENT AND THE DIAGNOSIS KIT FOR DYSPROTHROMBINEMIAS PCT/BR2005/000171 - Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Cleyson Valença Reis; Paulo Lee Ho; Celso Romero Ramos - August 2005, 24

KUNITZ-TYPE RECOMBINANT INHIBITOR PCT/BR2005/000185 - Ana Marisa Chudzinski-Tavassi; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); União Química Farmacêutica Nacional S/A. Ana Marisa Chudzinski-Tavassi; Durvanei Augusto Maria; Isabel de Fátima Correia Batista; Paulo Lee Ho - September 2005, 15

LOPAP-BASED PHARMACEUTICAL COMPOSITIONS AND USES THEREOF PCT/BR2006/000180 - Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Cleyson Valença Reis; Paulo Lee Ho; Celso Raul Romero Ramos ; Sandra Helena Poliselli Farsky; Márcio Fritzen - September 2006, 08

KUNITZ-TYPE RECOMBINANT INHIBITOR PCT/BR2008/000078 - Ana Marisa Chudzinski-Tavassi; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); União Química Farmacêutica Nacional S/A. Ana Marisa Chudzinski-Tavassi; Durvanei Augusto Maria; Isabel de Fátima Correia Batista; Paulo Lee Ho - March 2008, 14

PEPTIDES, COMPOSITIONS, AND USES THEREOF PCT/IB2009/050237 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Janaina de Souza Ventura; Linda Christian Carrijo Carvalho - January 2009, 22

PROCESSO DE OBTENÇÃO DE PROTEASE ATIVADORA DE PROTROMBINA RECOMBINATE (LOPAP) NA FORMA MONOMÉRICA; PROTEASE ATIVADORA DE PROTROMBINA RECOMBINATE (LOPAP), SEQÜÊNCIA DE AMINOÁCIDOS DA PROTEÍNA RECOMBINANTE ASSIM OBTIDA E USO COMO AGENTE DESFIBRINOGENANTE E KIT DIAGNÓSTICO PARA DESPROTROMBINEMIAS PI0403882-7 - Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Cleyson Valença Reis; Paulo Lee Ho; Celso Raul Romero Ramos ; Sandra Helena Poliselli Farsky; Márcio Fritzen - August 2004, 24

COMPOSIÇÕES FARMACÊUTICAS BASEADAS EM LOPAP E USOS DAS DITAS COMPOSIÇÕES PI0504199-6 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Márcio Falci; Durvanei Augusto Maria; Cleyson Valença Reis - September 2005, 08

PROCESSO DE OBTENÇÃO DE UM INIBIDOR DE PROTEASES DO TIPO KUNITZ A PARTIR DE UMA BIBLIOTECA DE cDNA DE GLÂNDULAS SALIVARES DO CARRAPATO AMBLYOMMA CAJENNENSE: SEQUÊNCIA DE OLIGONUCLEOTÍDEOS DO CLONE, E SEQUÊNCIA DE AMINOÁCIDOS DA PROTEÍNA RECOMBINANTE, PROTEÍNA RECOMBINANTE; PROCESSO PARA DETERMINAÇÃO DA ATIVIDADE INIBITÓRIA SOBRE O FATOR X ATIVADO, PROCESSO PARA DETERMINAÇÃO DA ATIVIDADE ANTICOAGULANTE EM PLASMA, PROCESSO PARA DETERMINAÇÃO DA ATIVIDADE APOPTÓTICA EM LINHAGENS DE CÉLULAS TUMORAIS HUMANAS E MURINAS, PROCESSO DE DETERMINAÇÃO DE ATIVIDADE ANTI-METASTÁTICA EM TUMOR DE MELANOMA, PROCESSO DE DETERMINAÇÃO DA ATIVIDADE ANTI-CÂNCER, IN VITRO E IN VIVO, USO DO RECOMBINANTE EM DIFERENTES MECANISMOS HOMEOSTÁTICOS (COAGULAÇÃO E RESPOSTA IMUNOLÓGICA), ANTI-PROLIFERATIVOS, ANTI-APOPTÓTICOS E ANTI-ANGIOGÊNICOS PI0406057-1 - Ana Marisa Chudzinski-Tavassi; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); União Química Farmacêutica Nacional S/A. Ana Marisa Chudzinski-Tavassi; Durvanei Augusto Maria; Isabel de Fátima Correia Batista; Paulo Lee Ho - September 2004, 15

PURIFICATION AND CHARACTERIZATION OF A PROTHROMBIN ACTIVATOR FROM THE BRISTLED OF LONOMIA OBLIQUA US10/501,238 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Chudzinski-Tavassi; Cleyson Reis - January 2003, 29

PROCESS FOR OBTAINING RECOMBINANT PROTHROMBIN ACTIVATING PROTEASE (RLOPAP) IN MONOMERIC FORM; THE RECOMBINANT PROTHROMBIN ACTIVATING PROTEASE (RLOPAP) AS WELL AS ITS AMINO ACID SEQUENCE; THE USE OF THIS PROTEASE AS A DEFIBRINOGENASE US11/574,213 - Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Cleyson Valenca Reis; Paulo Lee Ho; Celso Romero Ramos - August 2005, 24

KUNITZ-TYPE RECOMBINANT INHIBITOR US11/724,557 - Ana Marisa Chudzinski-Tavassi; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); União Química Farmacêutica Nacional S/A. Ana Marisa Chudzinski-Tavassi; Durvanei Augusto Maria; Isabel de Fátima Correia Batista; Paulo Lee Ho - March 2008, 14

METHODS FOR GROWING TISSUE WITH LOPAP-BASED PHARMACEUTICAL COMPOSITIONS US12/066,192 - Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Cleyson Valença Reis; Paulo Lee Ho; Celso Raul Romero Ramos ; Sandra Helena Poliselli Farsky; Márcio Fritzen - September 2006, 08

PEPTIDES, COMPOSITIONS, AND USES THEREOF US12/863,922 - Ana Marisa Chudzinski-Tavassi; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Ana Marisa Chudzinski-Tavassi; Janaina de Souza Ventura; Linda Christian Carrijo Carvalho - January 2009, 22

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