Andréa Dessen is a researcher at the Structural Biology Institute (IBS) in Grenoble, France, as well as a the Laboratório Nacional de Biociências (LNBio) de Campinas. She is also a professor at the Biology Institute at Unicamp (in graduate courses in Genetics and Molecular Biology). After obtaining her undergraduate diploma in chemical engineering (1987), she did a PhD at New York University (1987-1993) and two postdoctoral fellowships: the first one at Albert Einstein College of Medicine in New York (1993-1995) and a second one at Harvard Medical School in Boston (1995-1997). Her research interests are focused on bacterial infection mechanisms, and include toxin secretion systems, virulence factors, and the bacterial cell wall formation pathway. (Source: Lattes Curriculum)
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Bacterial resistance to antibiotics is a pressing, worldwide problem, and the 'drug development void' of the last several years has permitted that major human pathogens become resistant to all antibiotics, including 'last resort molecules'. This reality demands a multi-disciplinary effort towards the exploration of new ideas that could lead to the development of treatments that explore ye…
The bacterial cell wall is a complex three-dimensional structure that protects the cell from environmental stress, ensures its shape, and plays key roles in cell division and wall elongation processes. In addition, the cell wall serves as an attachment site for a number of virulence factors and secretion systems, that are necessary not only for infection but often for bacterial survival. …
Since Fleming's accidental discovery of penicillin, several other compounds with antibiotic activity have been used and have revolutionized Medicine in the treatment of infectious diseases. Despite the great advance in the development of these drugs, an unexpected factor is growing fast: the resistance of pathogenic microorganisms to antibiotics. Since pathogens inevitably become resistan…
The Peptidoglycan (PG) is one of the main components of the bacterial cell wall, being responsible to maintain the form and integrity of the cell. As an essential component for bacterial survival and found only in prokaryotic organisms, the PG biosynthesis has been widely explored for the development of antibiotics, even in the face of the global crisis caused by the antibiotic resistance…
The bacterial cell wall defines morphology and protects bacteria from external stress. Biosynthesis of its major component, peptidoglycan, occurs via a complex and dynamic process involving protein-protein interactions between PBPs (Penicillin Binding Proteins) and members of the elongasome. Due to the emergence of antibiotic resistant pathogenic bacteria, the development of new drugs and…
(Only some records are available in English at this moment)
Most bacteria rely on the secretion of proteins to adapt and survive in the environment. This is also true for pathogens, which secrete virulence factors to colonize and stablish infections in their hosts. The Gram-negative pathogen Acinetobacter baumannii is an example, since it uses its Type II Secretion System (T2SS) to secrete enzymes that assist in nutrient acquisition and modulation…
Antibiotics have been used to treat infectious diseases for decades and are arguably the most successful drugs developed in history. However, the wide use and misuse of these drugs have selected multi-drug resistant organisms, allowing bacteria to proliferate even in their presence. Moreover, many resistance elements are readily spreading among different bacterial strains, increasing the …
The cell wall is an essential structure for bacterial survival, being responsible for several vital cellular functions such as division, elongation, secretion of virulence factors, and adhesion. Its main constituent is the peptidoglycan, a polymer formed by polymerized glycan chains cross-linked by stem peptides. The enzymes which participate in peptidoglycan synthesis act in an orchestra…
(Only some records are available in English at this moment)
| 2 / 2 | Completed research grants |
| 11 / 11 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 17 / 17 | All research grants and scholarships |
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