CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
Pharmacist from the Federal University of Juiz de Fora, PhD from the Department of Immunology and Post-Doctor from the Department of Pharmacology at USP São Paulo. Experience in administration acquired for 4 years as deputy director of the Laboratory of Applied Toxinology (LETA) at Instituto Butantan. I have been Research Leader at the Immunoregulation Unit since 2004 and Co-founder and Deputy Coordinator of the Zebrafish Platform since 2015. Experience in managiment of research and innovative projects, including coordinating preclinical toxicology studies using experimental models of immune-mediated inflammatory diseases. (Source: Lattes Curriculum)
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In the venom of Thalassophryne nattereri a new family of proteins named Natterin was identified, which was expanded by the inclusion of new members reaching a total of 331 species that present 859 natterin or natterin-like genes. The natterin-like genes do not have orthologs described in mammals, but in fish. Among the 109 species of fish that have one or more natterin-like genes, the zeb…
The Natterin family of proteins was found for the first time in the venom gland of T. nattereri in five orthologous which present in the C-terminal portion an aerolysin domain, thus being able to interact with other proteins to form functional complexes involved in the engulfment of pathogens microbials, intracellular trafficking and phagosome modulation. The aerolysin family belongs to a…
Neutrophils, the most abundant immune cells in the circulation, are key players in acute inflammation. Excessive neutrophil recruitment is observed in traumatic and ischemic injuries, autoimmunity, and sterile liver injury and consequent neutrophil activation results host tissue injury. Therefore, understanding mechanisms of neutrophil recruitment is of major physiological and pathophysio…
Venomous fish are responsible for numerous accidents involving humans in the north and northeast regions of Brazil, Thalassophryne nattereri being the most common of them. T. nattereri venom causes chronic inflammation, impaired tissue repair and muscle necrosis in poisoned victims. In the inflammatory process, some cells such as neutrophils, monocytes and macrophages are recruited by inf…
The venom of the Thalassophryne nattereri fish (VTn) contains a protein family called Natterin, responsible for symptoms such as pain, edema, and necrosis in humans. This family includes four orthologs (Natterin-1 to -4) with similar structures, containing a DM9/DM9 domain at the N-terminal and an Aerolysin domain at the C-terminal, the latter being associated with pore formation. Subsequ…
Thalassophryne nattereri, known as niquim, is a venomous fish from Brazil that has caused serious medical accidents. Studies by our group have identified a new family of proteins in the venom of this fish, the Natterins, with kininogenic activity and capable of reproducing symptoms of human poisoning in mice. In 2021, the Natterina family grew, incorporating 331 species that encode 859 na…
The Natterin family was identified in the venom of Thalassophryne nattereri, which was expanded by the inclusion of 331 species that have 859 natterin or natterin-like genes. These do not have orthologs in mammals, but in fish. Among the 109 species of fish that have one or more genes, the zebrafish (Danio rerio) has 10 that encode 11 proteins. Although the many biological functions for N…
In the venom of Thalassophryne nattereri a new family of proteins named Natterin was identified, which was expanded by the inclusion of new members reaching a total of 331 species that present 859 natterin or natterin-like genes. The natterin-like genes do not have orthologs described in mammals, but in fish. Among the 109 species of fish that have one or more natterin-like genes, the zeb…
The Nattering family of proteins found in Thalassophryne nattereri fish venom has five orthologs (1 - 4 and -P) with N-terminal (DM9) and C-terminal (aerolysin) domains. Nattering-like protein sequences can be found in different immune defense cells of various venomous or non-venomous fish species. Moreover, recent studies point to the participation of Nattering-like proteins in immune de…
The family of Natterins, found in the venom of the fish Thalassophryne nattereri, has five orthologs (1 - 4 and -P) with N-terminal (DM9) and C-terminal domains (aerolysin). Natterin-like protein sequences can be found in different immune defense cells of various species of non-venomous and venomous fish; yet recent studies have shown the participation of Natterin-like proteins in the imm…
(Only some records are available in English at this moment)
Neutrophils, the most abundant immune cells in the circulation, are key players in acute inflammation. Excessive neutrophil recruitment is observed in traumatic and ischemic injuries, autoimmunity, and sterile liver injury and excessive neutrophil activation results host tissue injury. Therefore, understanding mechanisms of neutrophil recruitment is of major physiological and pathophysiol…
Results from our research group have shown that the memory response induced by T. nattereri venom in Balb/c mice is characterized by a chronic inflammation containing IL-17A-producing neutrophils. Moreover, we identified IL-17A retained in neutrophil extracellular traps (NET) in peritoneal inflamed cavity and spleen. Using the antagonist antibody of the IL-1 receptor (IL-1Ra) or blocking …
Recently we demonstrated that Thalassophryne nattereri (Niquim) fish venom induces the formation of a protective immune response characterized by memory B cells (Bmem) and the long-lived antibody-secreting cells (ASC). From a combined in vivo and in vitro approaches we have demonstrated that the generation of ASC (B220neg) on BALB/c mice is related to the production of survival factors fr…
| 1 / 1 | Ongoing grants |
| 9 / 3 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 19 / 9 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 35 / 19 | All research grants and scholarships |
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