CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Farmácia from Universidade de São Paulo (2004). Has experience in General Biology, acting on the following subjects: snake venom, proline-rich peptides, bradykinin-potentiating peptides, bothrops jararaca and toxin. (Source: Lattes Curriculum)
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Triple-negative breast cancer (TNBC) is the most invasive among all subtypes, and 46% of patients have metastasis reducing their survival rate. To metastasize, tumor cells need to separate from the tissue of origin and reach the circulation, becoming circulating tumor cells (CTCs). CTCs then need to survive and colonize metastatic sites. In the case of brain metastasis, TNBC cells, in add…
Cancer is the third most frequent cause of death in the world, and metastasis is responsible for over 90% tumor-associated mortality. The most common locations of metastasis are the lungs and bone marrow. It has been demonstrated that the stromal cell-derived factor-1 (SDF-1)-CXCR4 axis plays an important role in bone-marrow metastasis. In conditions of chronic inflammation or tissue dama…
Cancer is the third most frequent cause of death in the world, and metastasis is responsible for over 90% tumor-associated mortality. The most common locations of metastasis are the lungs and bone marrow. It has been demonstrated that the stromal cell-derived factor-1 (SDF-1)-CXCR4 axis plays an important role in bone-marrow metastasis.In conditions of chronic inflammation or tissue damag…
Glioblastoma multiforme (GBM) is one of the most aggressive and treatment-resistant brain tumors, with a median survival of only 15 months after diagnosis. This project aims to investigate the potential of DNA aptamers, in combination with standard chemotherapy (temozolomide - TMZ) to modulate epigenetic pathways in GBM. The aptamer Apt9, previously characterized as having high affinity f…
Breast cancer is the most common cancer among women, accounting for 15.5% of female cancer deaths. The triple negative subtype (TNBC) is highly aggressive and is associated with a worse prognosis. Brain metastasis is one of the main causes of death from the disease and studies indicate that the acquisition of a phenotype similar to GABAergic neurons facilitates colonization in the brain. …
The aim of this study is to analyze the polarization of human macrophages induced bythe secretome of chemoresistant and metastatic breast cancer cells, in order to understand therelationship between the tumor microenvironment, especially tumor-associated macrophages,and chemoresistance and metastasis. Understanding this relationship is fundamental for thedevelopment of new therapeutic app…
(Only some records are available in English at this moment)
As the most common solid extracranial tumor in children, Neuroblastoma is responsible for 15% of infant mortality related to Cancer. Children older than one year with Neuroblastoma have a low chance of surviving (only 34%), with recurrence in more than 50% of the cases, and recurrent tumors are resistant to treatments. Chemotherapy is the standard treatment to fight Cancer, however, resis…
Cachexia syndrome is a multifactorial metabolic syndrome that frequently develops in chronic clinical conditions such as cancer. The cachectic condition affects most cancer patients and is responsible for worsening the prognosis of these patients that are already debilitated. Cachexia is associated with the loss of adipose tissue and, especially, muscle tissue, resulting in an expressive …
(Only some records are available in English at this moment)
Triple negative breast cancer (TNBC) corresponds to approximately 15% of breast cancer cases and remains the most challenging subtype to treat, due to its marked aggressiveness, high recurrence rate, and pronounced resistance to chemoterapy. To survive and proliferate within the tumor microenvironment, tumor cells often present an altered metabolism, known as metabolic reprogramming. The …
Neuroblastoma has high recurrence rates and is often resistant to traditional treatments. Advanced cases, especially those involving metastasis, face poor survival outcomes, largely due to drug resistance. Such resistance significantly limits effective treatment options and underscores the urgent need to understand and target mechanisms driving chemoresistance in neuroblastoma. A promisin…
Neuroblastoma, an important cause of mortality in pediatric oncology, presents as metastatic disease in approximately 50% of patients. The relation of NO (nitric oxide) with the neuroblastoma progression has been studied in our laboratory LEM³ (Laboratory of Study of Molecular Mechanisms of Metastasis). We found that NO induced by Bj-PRO-10c, a peptide from Bothrops jararaca venom, impart…
| 5 / 3 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 17 / 13 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 29 / 23 | All research grants and scholarships |
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