Abstract
Recent studies show that the reaction of deoxyhemoglobin and nitrite yields small but sustained amounts of s-nitrosohemoglobin (bCys93-(NO)HbFe2+), a Hb species where the Hb b chain cysteine 47 residue is found s-nitrosated. It has been hypothesized that s-nitrosohemoglobin somehow releases NO or NO equivalents that promote vasodilation during the hemoglobin R/T allosteric transition upon…