CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Escócia
bachelor's at Bachelor of Science - BSc (Hons) from King s College London (1988) and doctorate at Doctor of Philosophy - DPhil(Oxon) from University of Oxford (1994). Has experience in Biochemistry, focusing on Metabolism and Bioenergetics, acting on the following subjects: glioma, câncer, ácidos graxos poliinsaturados, células tumorais and metabolismo. (Source: Lattes Curriculum)
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Gliomas are known for their poor prognosis and tendency to develop resistance to chemotherapies currently available in the clinic. There is evidence of the ability of polyunsaturated fatty acids (PUFAs) of the n-3 family, eicosapentaenoic acid (20:5 n-3) (EPA) and docosahexaenoic acid (22:6 n-3) (DHA), to interfere with resistance to chemotherapy in various tumours. PUFAs can influence as…
Autonomic dysfunction and the consequent activation of the renin-angiotensin system are the main determinants of the deleterious effects of hypertension. Increased availability of angiotensin II (Ang II) within brain autonomic areas activates intracellular signaling pathways thus augmenting neuronal activity and resulting in sympathoexcitation that characterizes the neurogenic hypertensio…
The polyunsaturated fatty acid (PUFA) of the n-6 family, octadecatrienoic acid (18: 3 n-6) or gamma-linolenic acid (GLA), is an inhibitor of glioma cell proliferation and migration. GLA and the n-3 PUFA's, eicosapentaenoic (20:5 n-3) (EPA) and docosahexaenoic (22:6, n-3) (DHA) acids, can influence various aspects of cell proliferation and death, as well as interfere with the migration and…
(Only some records are available in English at this moment)
Gliomas are tumors originated from glial cells and have basically a histological classification, which is divided into grades. The grade IV glioma, also known as glioblastoma is the most aggressive and has the worst prognosis with a high rate of recurrence. The correct classification of the tumor is an important criteria in the choice of therapies, however, the current methodology for det…
Cancer is a chronic disease that occurs due to uncontrolled growth of cells. The disease comprises gliomas which are brain tumors originating from glial cells. The most widely used treatments to combat these tumors, in addition to surgery, are chemotherapy and radiotherapy. Despite the considerable effect in reducing the number of cancerous cells, in some cases failure occurs due to capac…
Inflammation is a protective response against any physiological stimulus that disturbs natural tissue homeostasis. It can be modulated by several factors, among them, eicosanoids. These are inflammatory lipid mediators derived from arachidonic acid metabolism by the enzymes cyclooxygenase (COX) and lipoxygenase (LOX). Exogenous substances can influence eicosanoid synthesis, such as gamma-…
(Only some records are available in English at this moment)
| 18 / 15 | Completed research grants |
| 18 / 6 | Completed scholarships in Brazil |
| 36 / 21 | All research grants and scholarships |
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