João Valdir Comasseto

• Abstract

  Organic compounds of selenium and tellurium have been known for over 160 years. However, their application in organic synthesis and demonstration of their importance in biology only occurred from the second half of the 20th century. Our group has dedicated to this theme for over 3 decades, having developed novel synthetic methodologies, especially those based on tellurium organic compound…

  Preparation and application of chiral compounds containing chalcogens, AP.TEM

• Abstract

  Screening of new enzymes for enantioselective reactions using microorganisms isolated in Brazil. The prospecting of microorganisms will be carry out with samples from two Brazilian Biomes: Mata Atlântica [studies carried out in the context of the Biota Program (2001-04)]; Amazônia [Parque Nacional Pacaás Novos, Rondônia State (Madeira Watershead)]. Enrichment and isolation of chemolitotro…

  Bioprospection on the metabolism of prokaryotes from Brazilian biomas: exploitation of microbial transformations for synthesis of chiral pharmaceuticals and bioactives compounds, AP.BTA.R

• Abstract

  The focus of this project consists in the preparation and applications of chiral molecules containing the elements selenium and tellurium. Emphasis will be given to the use of environmentally friendly reaction conditions, such as the biocatalysis in aqueous medium, exploring the Brazilian biodiversity, and the development of solventless reactions. Some of the reactions to be developed wil…

  Preparation and applications of chiral compounds containing selenium and tellurium, AP.TEM

(Only some records are available in English at this moment)

• Abstract

  This post-doctoral project has as a goal make enzymatic reactions of organic compounds containing chalcogenos using immobilized microbial cells in marine and terrestrial fungi in biopolymers (chitosan and microfibroina silk). The microbial cells when immobilized may confer greater stability to the biocatalyst, and enzymatic reactions can be performed on a larger scale. The reactions will …

  Immobilization of microorganisms: application in reduction reactions of organic compounds containing chalcogens, BP.PD
• Synthesis and Biological Evaluation of Selenium and Tellurium Compounds as Inhibitors of the 20S proteasome, BP.PD
• Use of Bio-polymer PHB in the Preparation of ²-Hydroxy e ²-Amino-chalcogenide enantiopure, BP.IC