Abstract
The exosome is a 3'-5' exoribonucleolytic complex present in many organisms, from archaea to higher eukaryotes. It is involved in processing and degradation of different kinds of RNAs. In archaea, the exosome is composed of three different subunits, two containing RNase PH domains, and one containing RNA binding domains KH and S1. Structural data on the archaeal exosome show that the two …