CV Lattes
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Universidade de São Paulo (USP). Instituto de Biociências (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Biociencias from Universidade de São Paulo (1991), master's at Biociencias from Universidade de São Paulo (1994) and doctorate at Integrative Biology from University of California (2002). Has experience in Genetics, focusing on Human and Medical Genetics, acting on the following subjects: genetica de populacoes, hla, evolucao, bioinformática and fiologeografia. (Source: Lattes Curriculum)
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Admixture among populations produces genomes that are a mosaic of different ancestries. This mixing can originate novel genetic combinations, which are the potential substrate for adaptive evolution and can also modulate phenotypes, including diseases. As a consequence, understanding the genetic consequences of admixture is of both evolutionary and biomedical interest. Here, we investiga…
Organisms often make self-sacrifices that help groupmates. Despite the costs, such actions are ultimately worthwhile because individuals benefit other copies of their own genes. From this genetic perspective, a selfish gene would do best if it could measure its relatedness to the group and adjust the level of cooperation in proportion to the share of the benefits that go to other copies o…
Balancing selection refers to a class of selective regimes that increase genetic variation with respect to neutral expectations. Forms of balancing selection include heterozygote advantage, frequency-dependent selection, and selection which varies over space or time. Although the analysis of genomic data has brought rapid progress to our understanding of how demography and selection inter…
We propose a new evolutionary and environmental synthesis of Amazonian biodiversity that will seek to answer 11 key research questions on 4 target-taxa (butterflies, plants, birds, primates): Question 1 asks where biodiversity is distributed in Amazônia. We will develop the most complete georeferenced database to date for Amazonian vascular plants and terrestrial vertebrates and then use …
(Only some records are available in English at this moment)
Natural selection can result in an increase of genetic differentiation between populations, in the case where locally adapted variants differ among populations (Novembre and Di Rienzo 2009) . Natural selection can also potentially act in the opposite direction, maintaining shared diversity among populations, when selection favors similar sets of alleles in distinct populations. Finally, s…
Sickle cell disease is a heritable, monogenic blood condition with multisystem effects that affects more than 13 million people worldwide. Originating in Africa, most of the alleles causing the disease were introduced to Brazil during the colonial period, along with the forced migration of enslaved Africans. Since then, the combined effects of admixture and recombination have allowed alle…
Dictyostelium discoideum is a social amoeba that displays a unique behavior during periods of food scarcity. Under starvation, the unicellular individuals produce membrane proteins that promote cell adhesion and the resulting multicellular aggregate moves towards a better living environment. There, some of the cells will differentiate into a stalk that supports a spore head, formed by the…
Admixed populations are an important repository of evolutionary, demographic, and genetic information. Their study provides information about their history and evolutionary dynamics. In America, populations have predominantly European, African, and Native American ancestry. In addition to the contributions of admixture, natural selection and genetic drift have shaped population variabilit…
(Only some records are available in English at this moment)
This project aims to explore the decoupling process between sickle cell disease (SCD) and African ancestry within the Brazilian population, with a focus on understanding how demographic factors such as assortative mating and sex bias shape genetic diversity in admixed populations. The research builds on findings from a FAPESP-funded undergraduate and Master's project, which revealed a si…
Throughout this undergraduate research project, our focus is to investigate genetic diversity in Dictyostelium discoideum's "greenbeard genes," namely tgrB1 and tgrC1. This highly polymorphic gene pair is activated at the beginning of the social phase in the amoeba's life cycle, playing a crucial role in an allorecognition system during aggregation. The dynamics of this system can be conc…
To understand the interplay between demographic and selective processes inshaping genetic variation, two key quantities of interest are genetic load andthe efficacy of selection, which is the contribution of selection to the rateof change of the genetic load. Demographic processes such as population splits,bottlenecks and population growth can bring about changes in the magnitude ofgeneti…
The HLA genes are the most polymorphic loci of the genome, and also the most associated with disease. This places HLA genes among the most studied genes in the genome. However, their extreme polymorphism imposes challenges to methods of expression quantification, and as a consequence the study of HLA expression and regulation is still in its infancy. In our main project, we have developed…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 8 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 24 / 12 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 41 / 26 | All research grants and scholarships |
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