CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Curso de Ciências Moleculares from Universidade de São Paulo (1994), master's at Physic from Universidade de São Paulo (1997) and doctorate at Physic from Universidade de São Paulo (2001). Has experience in Byophysics, focusing on Molecular Biophysics (Source: Lattes Curriculum)
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Mimetic models of biological membranes are widely used in biophysical studies as they allow control of components and easy handling. The most commonly used conventional models consist of a symmetric lipid bilayer with a few components. However, the use of more specific and realistic models is important in several aspects. In this project, we intend to study and use mimetic models in three…
Fluorescence is one of the most versatile techniques applied in biophysical studies. The fluorescence lifetime is on the order of nanoseconds, coinciding with the timescale of several relevant processes at the molecular level, such as conformational changes of biomolecules. The fluorescence can be directly measured in biomolecules such as proteins and peptides that have fluorescent aminoa…
Differential scanning calorimetry is a technique that allows the measurement of the specific heat of a sample subjected to a temperature scan. This technique has been widely used to relate thermal properties of materials with their physical properties. In special, the DSC technique is traditionally used in the topics proposed in the Thematic Project to which this proposal is linked, such …
(Only some records are available in English at this moment)
Biological membranes are essential for life, as they guarantee adequate protection, structuring and permeability to the cell, and are composed mainly of proteins and lipids, which form a lipid bilayer that provides their structural basis. The plasma membrane also has a rich glycocalyx, formed by glycated domains attached to proteins and lipids in its outer monolayer, which are responsible…
Detergents are routinely used to solubilize the components of cell membranes, whose structural motif is given by the lipid phase. Therefore, the study of the physicochemical aspects of the detergent/lipid interaction is important both for a better understanding of the solubilization process and for the proposition of more efficient solubilization protocols. Most of these studies, however,…
Unconventional food plants (UFPs) were described by the biologist Valderly Kinupp as native or exotic edible plants that can be found in backyards, flowerbeds and vacant lots. In Brazil, it is estimated that at least 10% of the native flora is food, totaling an average of 5,000 species. In addition, they are classified as functional foods, as they are rich sources of essential vitamins, a…
The selection of microorganisms resistant to conventional drugs, caused mainly by the indiscriminate use of antibiotics, is a problem in the world health scenario, which has led the scientific community to seek new therapeutic strategies. Antimicrobial Peptides (AMPs) are naturally modulators of the innate immune system of several organisms and have been shown to be a promising alternativ…
(Only some records are available in English at this moment)
Liposomes are reliable biomimetic models of the complex biological membrane and have a great potential as drug delivery systems. Fusogenic liposomes, based on cationic (e.g. DOTAP) and fusion promoter (e.g. DOPE) lipids, are interesting delivery systems because of their effective intracellular delivery of encapsulated materials, in comparison with conventional liposomes that usually under…
The possibility to study functioning mechanisms and the complexity of a biological system using self-organized systems is of great interest in the scientific community. A major part of the biological processes take place at the biological membrane interface and its modeling with Langmuir monolayers and lipid bilayers are valuable because of their easy preparation and molecular control. Th…
Giant unilamellar vesicles (GUVs) are a good model of biological membranes for the investigation of biological processes. Their use allows observation of the studied events by optical microscopy. In this project, we propose to study various biophysical aspects of GUVs composed of negatively charged lipids in the presence of an electric field - electrical pulse, and during fusion with memb…
| 1 / 1 | Ongoing grants |
| 7 / 6 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 13 / 9 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 25 / 20 | All research grants and scholarships |
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