CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas - Modalidade Médica from Universidade Federal de São Paulo (1995), master's at Biology from Universidade Federal de São Paulo (1998) and doctorate at Biology from Universidade Federal de São Paulo (2002). Has experience in Biochemistry, acting on the following subjects: glicolipídeo, galactofuranose, anticorpo monoclonal, leishmania and paracoccidioides brasiliensis. (Source: Lattes Curriculum)
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In addition to forming a physical barrier, pulmonary epithelial cells act in the respiratory tract as sensors that interact and respond to different microorganisms and particles. Our group has studied the response of pulmonary epithelial cells to infection with pathogenic fungi in humans. We have observed that the different species of Paracoccioidioides, for example, interact with pulmona…
Over the past 10 years, our group has been studying the mechanisms involved in cytokine secretion that result from the interaction between human pulmonary epithelial cells and pathogenic fungi of the genus Paracoccidioides. During one of these studies, we found out that P. brasiliensis modulates alfa3 integrin expression in epithelial cells, increasing the expression of this protein in th…
During an infection, epithelial cells interact with pathogens or their products, and can secrete cytokines and chemokines, these molecules, in turn, modulate the immune system. Paracoccidioides brasiliensis and Histoplasma capsulatum are two dimorphic fungi that cause systemic mycoses in humans. Recently, we found that both species induce the secretion of IL-6 and IL-8 cytokines in human …
Several studies about interaction of fungi of medical importance with host were performed using myeloid cells, which include macrophages, dendritic cells and neutrophils. By acting as structural barrier, lung epithelial cells constitute one of the first mechanisms of defense against inhaled particles and microorganisms. Besides, several groups have demonstrated that bacteria, fungi and ot…
Fungi of the genus Paracoccidioides are etiological agents of paracoccidioidomycosis, a systemic human mycosis that affects the lungs and other organs and is triggered by the inhalation of fungal propagules. Due to its route of infection, studies on the interaction between components of the pulmonary epithelial barrier (BEP) and Paracoccidioides are important to elucidate its pathogenicit…
Paracoccidioidomycosis is caused by the thermodimorphic fungus Paracoccidioides spp. and comprises a systemic human mycosis endemic in Brazil, being a public health problem in the country. For over 15 years, the Laboratory of Cellular Biology of Fungus-Host Interaction has been focusing its studies on the responses of lung epithelial cells when interacting with Paracoccidioides yeasts. In…
Paracoccidioidomycosis (PCM) is an endemic systemic mycosis with prevalence in Latin America, mainly in Brazil, caused by thermodimorphic fungi species of the genus Paracoccidioides. Infection occurs through the inhalation of conidia from the mycelial environmental phase of the fungus, which differentiate into yeasts in the host's lungs. Lung epithelial cells play an important role in mod…
Fungi of the genus Paracoccidioides cause systemic mycosis in humans called paracoccidioidomycosis. During an infection, epithelial cells can interact with the fungus, or its products, which can lead to the secretion of cytokines and chemokines that, in turn, modulate the immune system. In recent years, our group has verified that factors secreted by yeasts from different isolates and spe…
Paracoccidioidomycosis is caused by the fungal pathogen of the genus Paracoccidioides and is the most prevalent systemic mycosis in Latin America. About 80% of the cases occur in Brazil. And, due to the increasing number of cases of this mycosis in our country, studies about interactions between these fungi and host are essential to understand the events involved in the establishment of i…
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The lung epithelial cells play an important role in the immune system by producing cytokines and chemokines that act as chemoattractants for the recruitment of immune cells against stimuli. The modulation of these cytokines may occur by integrins, which are membrane proteins that participate in the pathogen-host interactions. Our group studies the interaction between epithelial cells and …
| 1 / 1 | Ongoing grants |
| 5 / 3 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 10 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 19 / 13 | All research grants and scholarships |
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