Nathalie Cella

• Abstract

  Maspin is an abundant protein in epithelia, and it has diverse biological functions. In the organism, maspin inhibits angiogenesis, tumor cell growth and invasion. Maspin deficiency results in lethality during embryogenesis. Though most studies have observed that maspin is a tumor suppressor gene, clinical studies suggest that maspin can be an oncogene or a tumor suppressor if it is found…

  Maspin in cell stress response and intercellular communication, AP.R

• Abstract

  Maspin (SERPINB5) is a tumor and metastasis suppressor gene identified in the mammary tissue in a search for genes which are downregulated in tumors compared to the normal organ. Now it is known that this protein is expressed by most epithelia. Maspin has diverse biological activities including regulation of cell adhesion, migration, proliferation and cell death as well as control of gene…

  Maspin - function and signaling pathways in the mouse mammary epithelium, AP.R

• Abstract

  Maspin (mammary serpin) is a tumor suppressor gene with diverse biological activities, among them regulation of cell adhesion, migration and death, oxidative stress response, gene transcription among others. Initially described in the mammary tissue, we now know that this protein is present in most epithelia and knockout mice do not survive beyond embryogenesis. Initial studies reported a…

  Molecular mechanisms underlying Maspin biological activities, AP.R

• Abstract

  Oxidative stress is known as one of the major factors causing cancer, cardiovascular and neurological diseases, and aging. Within this context, maspin is a tumor suppressor protein that also displays antioxidant properties. It has been reported that cytoplasmic maspin is able to prevent hydrogen peroxide (H2O2)-induced oxidative stress. On the other hand, previous data obtained by our gro…

  A possible regulatory role for nuclear maspin in response to oxidative stress, BP.IC

• Abstract

  Maspin (mammary serpin) is a 42 kDa protein which belongs to superfamily of serpins (serine protease inhibitor) due to sequence homology, however, its mechanism of action does not depend on protease inhibition as indicated by the adopted nomenclature. This protein was identified in 1994 during a search for genes expressed in normal mammary epithelial cells but absent in breast tumors. Onl…

  Role of maspin in cell migration and proliferation, BP.DR

• Abstract

  Cell migration is a vital process for most organisms because it is related to various physiological functions such as tissue organization, wound healing, and homeostasis. In unicellular organisms, it is an essential process for displacement, food capture, and defense. Alterations in migration regulatory pathways can trigger a number of diseases such as metastatic tumors. This process is r…

  The role of maspin on EGF induced cell migration, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Maspin (mammary serpin) is a 42 kDa tumor suppressor protein which belongs to superfamily of serpins due to sequence homology, however, its mechanism of action does not depend on protease inhibition. This protein was identified in 1994 during a search for genes expressed in normal mammary epithelial cells but absent in breast tumors. Among maspin biological effects are modulation of cell …

  Regulation of maspin phosphorylation by the EGFR pathway, BE.EP.DR