Ricardo Jose Giordano

• Abstract

  The animal facilities of the School of Pharmaceutical Sciences (FCF) and the Chemistry Institute of the University of São Paulo were unified in 1992 to create the Center for Research in Biomodels at USP. This was essential to adapt to the new demands of science. Since then, with substantial investments from the University and funding agencies, the FCF/IQ animal facility has been shaped un…

  Proposals for Improving the Operating Infrastructure of the Biomodels Research Center at USP, AP.PI

• Abstract

  Blood vessels play a central role in the most diverse physiological and pathological processes. Over the past few years, our group has been studying two important aspects of vascular biology: the process of formation of new blood vessels by angiogenesis and the molecular heterogeneity of vascular networks in different organs and tissues of the body. Understanding the molecular mechanisms …

  Molecular mechanisms of angiogenesis and vascular heterogeneity, AP.TEM

• Abstract

  Large scale mapping of antigens and epitopes is pivotal for developing immunotherapies but challenging, especially for eukaryotic pathogens, due to their large genomes. Here, we developed an integrated platform for genome phage display (gPhage) to show that unbiased libraries of the eukaryotic parasite Trypanosoma cruzi enable the identification of thousands of antigens recognized by seru…

  Uma metodologia refinada de phage display de genoma delineia a resposta de anticorpos humanos em pacientes com doença de Chagas, PUB.ART

• Abstract

  The concept of vascular heterogeneity is well accepted by the scientific community, playing an essential role in physiological and pathological processes. Since blood vessels are important in organogenesis, differentiation, and morphogenesis of tissues and organs, it becomes interesting to unveil the cerebral vascular diversity, identifying new molecular markers for such important organ. …

  Studies on the vascular heterogeneity of the nervous system, AP.R

• Abstract

  Angiogenesis, the formation of new blood vessels from pre-existing ones, is an important process in vertebrate organisms, in physiological and pathological conditions. Retinopathy, a primary reason for legal blindness in adults, is an example in which angiogenesis has a key role in disease formation and progression. Macular degeneration and diabetic and retinopathy of prematurity are dis…

  Development of peptidomimetic compounds for the treatment of retinopathy, AP.R

(Only some records are available in English at this moment)

• Abstract

  Angiogenesis is the name given to the process of forming new blood vessels from existing ones. The main factor inducing angiogenesis is VEGF (vascular endothelial growth factor), which binds to two tyrosine kinase receptors: VEGFR1 and VEGFR2. Although VEGFR2 is considered the primary target for drug development due to its high tyrosine kinase activity, in previous studies, we demonstrate…

  Structure and function of the VEGFR1 receptor: ligand binding site dynamics, BP.IC

• Abstract

  "Angiogenesis-dependent diseases", such as cancer and retinopathies, affect a large number of individuals. In addition to the suffering of these individuals, these diseases cause great socioeconomic impacts. In this context, the pharmaceutical industry has been committed to developing drugs with anti-angiogenic activity, especially with anti-VEGF activity. Although great strides have been…

  Rational drug design: development of angiogenesis inhibitors targeting VEGF and TIE1 receptor pathways, BP.PD

• Abstract

  Os vasos sanguíneos têm um papel central nos mais diversos processos fisiológicos e patológicos. Ao longo dos últimos anos, nosso grupo tem estudado dois aspectos importantes da biologia vascular: o processo de formação de novos vasos sanguíneos por angiogênese e a heterogeneidade molecular das redes vasculares nos diferentes órgãos e tecidos do corpo. Compreender os mecanismos moleculare…

  Molecular mechanisms of pathological angiogenesis, BP.TT

• Abstract

  O objetivo principal é montar um "pipeline" de "drug discovery" utilizando inteligência artificial (AI). Este pipeline já foi iniciado parcialmente no laboratório e será agora implementado, incluindo validação experimental dos achados pelo bolsista. A(o) bolsista será supervisionado por mim e pelo pesquisador principal João Carlos Setubal.

  Studying pathological angiogenesis: drug discovery using artificial inteligence., BP.TT

• Abstract

  A(a) bolsista irá auxiliar nos ensaios de proliferação e migração de células endoteliais, principalmente, ensaios envolvendo cultura de células endoteliais primárias (HUVEC), por exemplo. Será preciso ainda desenvolver linhagens celulares que expressam os receptores VEGFR-1 (FLT1) ou Tie1 humano em células não-endoteliais para realizar estudos de sinalização com o composto V2 e com o anti…

  Development of two new inhibotors of angiogenesis (VEGF and TIE1 pathways), BP.TT

(Only some records are available in English at this moment)