Marcelo Afonso Vallim

• Abstract

  Cryptocaccus neoformans and C. gattii are two fungal pathogens that infect humans with normal and suppressed immune systems, killing more than 500,000 people each year. Both species have hallmarks properties of having southern hemisphere origins, yet there is a limited focus on these neglected pathogens in countries like Brazil and Australia. The proposal aims to use the medium of a resea…

  The role of autophagy on the pathogenicity of Cryptococcus neoformans and as a potential drug target, AP.R SPRINT

• Abstract

  Fungal infections are often difficult to treat due to the inherent similarities between fungal and animal cells and the resulting host toxicity from many antifungal compounds. Cryptococcus neoformans is an opportunistic fungal pathogen of humans that causes life-threatening disease, primarily in immunocompromised patients. Since antifungal therapy for this microorganism is limited, many i…

  The role of autophagy in Cryptococcus neorformas high temperature (37°C) growth and virulence, AP.R

• Abstract

  The influence of xenobiotics compounds on environment and on living organisms has been reported as an imminent public health problem. Among them, we can List the contamination by Alkanes present in petroleum, hydrocarbons and organic contaminant substances from industrial effluents. Also, heavy metals are of particular interest because of their persistence in the environment contaminating…

  The evaluation of bioremediation potential of a yeast collection isolated from composting, PUB.ART

(Only some records are available in English at this moment)

• Abstract

  The opportunistic fungus Cryptococcus neoformans is of great medical importance, it can be founf in the most diverse environments, both rural and urban, and it affects serious problems in immunocompromised patients such as cryptococcal meningitis that is highly lethal if not treated. The search for drugs against eukaryotic pathogens is difficult, since there have low selective toxicity, r…

  Identification of molecular targets in Cryptococcus neoformans and the importance of AAP1 amino acid permease for virulence factors, BP.IC