Abstract
Normotensive and spontaneously hypertensive rats (SHR) show a significant decrease in blood pressure during the last period of pregnancy which is associated with vascular hiporeactivity to some vasoconstrictor agonists. These effects have been attributed to a higher modulation of nitric oxide (NO) and to an increased activity of nitric oxide synthase (NOS) eNOS. PI3-K/Akt phosphorylates e…