Alvaro Takeo Omori

• Abstract

  This proposal aims the development of alternative methodologies for the synthesis of some drugs used in the orotracheal (or endotracheal) intubation process. The intubation technique is critical in the context of the treatment of COVID-19 and requires the administration of several sedatives and neuromuscular blockers that must be administered before and during the procedure. During the se…

  Alternative methodologies in the synthesis of intubation drugs and Molnupiravir applying green and circular chemistry principles, AP.R
• 7th Advanced School on Organic Synthesis, AO.R

• Abstract

  This proposal aims to expand the applications of the use of carrot pieces in organic synthesis. This edible plant is used as a biocatalyst in reduction reactions of prochiral ketones, leading to alcohols with excellent values of enantiomeric excess and good conversion rates. Our research group demonstrated that this technique can be applied both in total synthesis (talampanel) and in synt…

  EXPANDING THE USE OF CARROT BITS (Daucus carota) IN ORGANIC SYNTHESIS - APPLICATIONS IN TOTAL SYNTHESIS OF BIOACTIVE MOLECULES, NOVEL SUBSTRATES AND THE DEVELOPMENT OF A SCALE-UP METHODOLOGY, AP.R

(Only some records are available in English at this moment)

• Abstract

  This proposal aims the synthesis and reactivity studies of substituted 7-azanorbornanes. Since this class of compounds is well investigated, mainly by the discovery of (-)-Epibatidine, the main objective is investigate the intramolecular Mannich reaction (developed by Rapoport and coworkers) with less complex substrates. Although the 5-endo-trig cyclization is unfavored according to Baldw…

  Synthesis of substituted 7-azanorbornanes by intramolecular mannich reaction: application to asymmetric synthesis of epibatidine, BP.MS