CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Medicina from Universidade de São Paulo (1990), master's at Psychiatry from Universidade Federal de São Paulo (1998) and ph.d. at Psychiatry from Universidade de São Paulo (2001). Has experience in psychiatry, acting on the following subjects: genes, bioinformatics, genomic, autism. (Source: Lattes Curriculum)
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A growing body of literature focus on women that has COVID-19 during pregnancy. Many of these studies analyse the impact of the infection on the infant neurodevelopment, whilst other works study the transcriptome of this group with RNA sequencing (RNA-Seq). Up to now, no study performed both transcriptome analysis and neurodevelopmental tests. Furthermore, only one work on pregnant women …
Neurodevelopmental disorders are polygenic and multifactorial. Besides the genetic component, evidences from animal and human studies indicate that environmental adversities and / or psychosocial stresses experienced early in life can trigger epigenetic changes that may influence brain plasticity, neural circuit connectivity and functioning. These changes may affect the adequate developme…
The obsessive-compulsive disorder (OCD) is the fourth most common psychiatric disorder and is related to significant disability, poor quality of life and disrupted family functioning. Despite the existence of effective therapeutic interventions for OCD (e.g. serotonin reuptake inhibitors and behavior psychotherapy), up to half of OCD patients do not respond satisfactorily with treatment. …
This study is part of a broader line of research being developed in the Program for Obsessive-compulsive Spectrum Disorders of the Institute of Psychiatry, Hospital das Clínicas, School of Medicine, University of São Paulo in collaboration with Program for Autism Spectrum Disorder of the same center. Along the phenotypic characterization studies and clinical trials developed by these rese…
Attention-deficit /hyperactivity disorder (ADHD) is one of the most common mental disorders of childhood and is associated with an important individual and social impact. Most affected individuals persist with symptoms or significant functional impairment into adulthood, which characterizes it as a chronic medical condition. In this mental disorder, genetic factors play an important role,…
(Only some records are available in English at this moment)
Exposure to prenatal insults, such as maternal stress, has been associated with an increased risk of adverse neurodevelopmental outcomes. Since the fetus is antigenically distinct from the mother, it is necessary to establish a tolerant immune response to prevent rejection of the developing organism. Although the mechanisms of maternal-fetal cross-talk responsible for homeostasis are not …
After the COVID-19 pandemics, it is key to understand its long-term consequences, such as the effects of SARS-CoV-2 infection during pregnancy on foetal neurodevelopment. Until now, no study has focused on the relationship between gene expression and neurodevelopment in the offspring of people infected by SARS-CoV-2 during pregnancy. This project aims at studying molecular pathways in pre…
In a pilot study, using a sample of 100 children from the ROC cohort , we evaluated Principal Components analysis (PC) from different measures of maternal exposure to gestational stress. Two PCs explained more than 70% of the data variability, the first one related to maternal psychic vulnerability (PC1) and the second one to metabolic vulnerability (PC2). Using a two-dimensional graph, w…
This project aims to determine the polygenic risk for characterizing exposure to gestational stress. Recently, modifications in the risk calculations of polygenic score (RPS) have been proposed to assess the prediction of individual risk, as well as the integration of information on exposure to environmental stress. The use of Multiple Polygenic Scoring (MPS) methodology has been used to …
The present work aims to analyze data from Module I, Project 1. We seek to evaluate the relationship between the number of placental exosomes of pregnants who are participating in a randomized clinical trial to test the effectiveness of an intensive home visit program (cohort "Visitation Program for Young Pregnant Women").
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 5 / 5 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 20 / 19 | Completed scholarships in Brazil |
| 29 / 28 | All research grants and scholarships |
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