CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduate at Biological Sciences from Universidade Estadual de Campinas (1985) and ph.d. from Universidade de São Paulo (1991). Post-doctoral studies at Univeristy of California at Los angeles (UCLA) from 1992-1994. Current position is Associate Professor at Department of Microbiology at University of Sao Paulo. Research experience in Genetics and Microbiology, focusing on Bacteriology, acting on the following subjects: bacterial genetics, gene regulation, stress response (Source: Lattes Curriculum)
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The transcription initiation is the most important regulatory step of gene expression, carried out by the transcription factors, but recent literature has increasingly reported the importance of post-transcriptional gene regulation. Among the most studied mechanisms are those mediated by small regulatory RNAs and RNA-binding proteins, that alter the stability and translation properties of…
Caulobacter crescentus is an oligotrophic alpha-proteobacterium important for recycling of organic matter generated mainly from decomposing plants. This bacterium is well adapted to survive in low nutrient environments and at low temperature, and has a differentiation step in its cell cycle. Multienzymatic complexes have vital roles in cell survival, mainly under stress conditions, where …
(Only some records are available in English at this moment)
The regulation of the cell cycle and stress response requires transcriptional and post-transcriptional mechanisms that mediate the concentration of mRNA transcripts in the cell and their translation. Therefore, RNA degradation processes have an important role in the cessation of response, nucleotide recycling, change in gene expression patterns and adaptation. The RNA degradosome is a mul…
To ensure a rapid and effective response to stress, a network of transcription factors and regulatory small RNAs (sRNAs) regulate gene expression by transcriptional and post-transcriptional mechanisms. Small regulatory RNAs regulate gene expression post-transcriptionally via base-pairing interactions with the targets, usually at the mRNA 5'-Untranslated Region, and so altering their stabi…
Transcription factors (TF) are usually considered to be poorly druggable, but this perception stems from the fact that eukaryotic TFs are predominantly intrinsically disordered proteins, which are indeed harder to inhibit with small molecules (10.1038/s41573-021-00199-0). Bacterial TFs, on the other hand, are structured and naturally regulated by small molecule allosteric modulators. The …
(Only some records are available in English at this moment)
Aconitase is a protein best known for its enzymatic action of catalyzing the conversion reaction from citrate to isocitrate in the Krebs cycle when bound to a FeS group. Additionally, in other organisms such as Escherichia coli, this protein in the Apo form (without FeS) is also able to bind RNA, changing its half-life and translation. However, in C. crescentus (an alphaproteobacterium co…
Caulobacter crescentus is an ±-proteobacterium that goes through distinct morphological changes during its cell cycle, making it an excellent model for the study of morphology and gene regulation. Under stress, such as cold-shock, C. crescentus adapts its metabolism to maintain its viability, involving changes in gene expression. On these conditions, RNA molecules tend to form stable seco…
Caulobacter crescentus is an ±-proteobacteria that lives in aquatic environments and is a key organism for the study of the cell cycle in prokaryotes, due to its asymmetric cell cycle that results in two distinct daughter cells. As an oligotrophic organism, it is able to colonize environments with low nutrient concentration and organic matter availability, experiencing nutritional stress.…
(Only some records are available in English at this moment)
This Doctorate project aims to characterize two regulatory systems from Caulobacter crescentus, FEC2 and FEC4. These systems comprise a sigma factor, an anti-sigma factor and a TonB-dependent receptor, and they are described in other bacteria as involved in the uptake of organic iron chelators (siderophores). Promoter expression assays and growth curves of mutant strains were performed in…
| 23 / 15 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 36 / 14 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 65 / 35 | All research grants and scholarships |
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