CV Lattes
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Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Pharmacy-Biochemistry from Hermínio Ometto College, Ph.D. in Toxicology from FCFRP-USP and Post-doctorate from the University of São Paulo. He is currently Associate Professor at the Department of Chemistry at FFCLRP-USP. He has experience in the field of Analytical Chemistry, working mainly on the following topics: stereoselective separation of pesticides, drugs and metabolites by HPLC and capillary electrophoresis, validation of methods, development of miniaturized techniques of preparation of samples and in vitro metabolism studies. The group's research focus is the development of chromatographic and electrophoretic methods to be used in studies of in vitro metabolism and biotransformation. (Source: Lattes Curriculum)
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In this new proposal, we aim to continue the project started previously (FAPESP 2018-07534-4) whose validity ended on 03/31/2021. The main objective of this project is the in vitro determination of enantioselectivity in the metabolism and enzymatic inhibition of chiral pesticides on the main cytochrome P450 (CYP450) enzymes involved in drug metabolism. These studies will be conducted with…
Quantification of analytes present in biological matrices requires the development of methods that are accurate and reproducible under various analytical conditions. Chromatographic and electrophoretic techniques (capillary electrophoresis) are techniques widely used for these purposes. These techniques have the main advantage of simplicity, rapid analysis and wide versatility. Our resear…
The quantification of analytes present in biological matrices requires the development of accurate and reproducible analytical methods under several conditions of analysis. Chromatographic and electrophoretic techniques (capillary electrophoresis) are techniques widely used for these purposes. These techniques have several advantages such as: simplicity, speed of the analysis and versatil…
The quantification of analytes present in biological matrices requires the development of analytical methods that should be precise, accurate and reproducible under several conditions of analysis. Chromatographic and electrophoretic techniques (capillary electrophoresis) are techniques widely used for these purposes. These techniques have several advantages such as: simplicity, speed of t…
(Only some records are available in English at this moment)
Methamidophos is a chiral pesticide whose enantioselective effects have already been observed under different environmental conditions and in vitro assays. In addition, it has been widely used for pest control in peanut, tomato, potato, bean, cotton, soybean and wheat plantations. Currently, as a pesticide, it has been banned in several countries due to its high degree of toxicity. Even w…
The intense use of pesticides in agricultural areas around the world exposes serious risks to the environment and human beings. The identification of water and food contaminated with penconazole shows that exposure of non-target species occurs and is of great concern. In vitro metabolism models can be used to evaluate pesticide metabolism. This technique has several advantages such as the…
Penconazole (PEN) is a chiral fungicide used mainly in grape crops against powdery mildew and rust disease. In a chiral environment, such biomolecules, enantiomers can interact differently leading to differences in metabolism, bioactivity and toxicity. Enantioselective studies involving PEN have already reported differences in the activity, metabolism and toxicity of its enantiomers. In a…
Worldwide, the pesticides use has been significantly increasing. Hence, non-target organisms, such as humans, may be more exposed to its toxic effects. Prothioconazole is a fungicide used in Brazil, the United States of America and European Union countries in cotton, barley, corn and wheat crops. Since it is a chiral fungicide, each enantiomer may interact differently in chiral environmen…
(Only some records are available in English at this moment)
Pesticide exposure represents a significant health concern with significant impacts reported for both acute and chronic exposure. Pesticide-drug interactions are believed to play a role in the toxicity of pesticides due to the inhibition of CYP450 forms responsible for drug metabolism by pesticides. These interactions can lead to adverse effects or even lack of drug activity due to the in…
Greening is a citrus plant disease caused by gram-negative bacteria and transmitted by insect vectors. Citrus greening disease has a severe impact in the citrus worldwide production. The economic loss caused by this disease, both in Brazil and the United States of America, is extremely significative with great revenue losses. There are no known curative methods to combat the citrus greeni…
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| 5 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 16 / 16 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 25 / 25 | All research grants and scholarships |
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