CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
PhD in Neurosciences at Universidade Federal de São Paulo (UNIFESP) based on neuronal plasticity following epileptic events. Postdoc in Molecular Biology (UNIFESP) and Stem Cell Therapy at Oswaldo Cruz Foundation (FIOCRUZ). Currently working as Associate Professor in Neurophysiology and PI of Neurophysiolgy lab (UNIFESP), focusing on experimental models of epilepsy and Alzheimer´s disease and potential treatments. (Source: Lattes Curriculum)
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The search for antiepileptogenic drugs remains as necessary today as it was in 2018, when we submitted our first funding proposal to FAPESP. Based on the advances achieved over the past five years of the project 2018/24561-5 (approved by FAPESP in 2020), we now propose a new phase of this investigation aimed at validating the hypothesis that cholinergic modulation by biperiden can interfe…
Alzheimer's Disease (AD) is characterized by progressive learning and memory loss, behavioral dysfunction, and changes in social interactions. The extensive deposition of the amyloid-² peptide (A²) in the form of senile plaques in the cortex and hippocampus and the presence of neurofibrillary tangles are the two main pathophysiological features of AD. In addition, AD is strongly associate…
Traumatic brain injury (TBI) is a public health problem, with considerable social and economic burden. TBI is one of the most important causes of secondary epilepsy. TBI leads to post-traumatic epilepsy (PTE) most likely by means of direct damage to the brain parenchyma, which in turn leads to neurodegeneration and inflammatory responses, as well as molecular, structural and electrophysio…
(Only some records are available in English at this moment)
Traumatic Brain Injury (TBI) has major impacts on the quality of life and can be considered the leading cause of death and disability in the world by 2030. One of the most important neurological consequences after TBI is the development of Post-Traumatic Epilepsy (PTE). Unfortunately, the relationship between traumatic brain injury and Epilepsy is not fully understood and PTE cannot be pr…
A Doença de Alzheimer (DA) é caracterizada por uma perda progressiva de memória e aprendizagem, disfunção comportamental e alterações nas interações sociais. A extensa deposição do peptídeo ²-amiloide (A²) na forma de placas senis presentes no córtex e hipocampo e a presença de emaranhados neurofibrilares são as principais características fisiopatológicas da DA. Além disso, a DA está fort…
Alzheimer's disease (AD) is a neurodegenerative disease that causes about 70% of dementia cases worldwide. With the advances of technologies in health care and medicine, the life expectancy of the world´s population has increased, but it is noted that this population aging is accompanied by an increase in the number of elderly people with AD. Therefore, considering the worldwide prevalenc…
AAlzheimer's disease (AD) is clinically characterized by progressive memory loss, behavioral and learning dysfunction, and cognitive deficits. Its main pathological features are the increase of ²-amyloid plaques (²) and neurofibrillary tangles of tau protein, as well as changes in microglial cells and cortisol levels. For the experimental study of AD, experimental models were developed i…
(Only some records are available in English at this moment)
Alzheimer's disease (AD) is the most common form of neurodegenerative dementia, responsible for 60-70% of cases globally. AD manifests memory and cognitive deficits linked to neuropathological changes like neuronal loss, neurofibrillary tangles, and amyloid-² (A²) plaques formed from amyloid precursor protein (APP) deposits. Microglia, vital immune cells in the brain, can initially clear …
The brain injury established after a traumatic brain injury (TBI) is the result of pathophysiological changes triggered at the moment of the accident (primary injury) that prolong for days and weeks (secondary injury). Inflammatory processes after the brain injury play a main role in the pathogeneses of TBI and may initiate changes related to behavioral deficits such as sleep disturbance,…
Alzheimer's disease is a fatal neurodegenerative disorder characterized by cognitive impairment and emotional disturbance resulted from selective neuronal dysfunction and synaptic loss. In addition to neuronal alterations and amyloid-beta deposition, the astrocytes - a type of glial cell widely found in central nervous system- become reactive in a state called astrogliosis. The nature of …