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Patricia Bianca Clissa

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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Bachelor's degree in Biological Sciences from Mackenzie University (1993), Master's degree in Basic Nuclear Technology from the Institute of Nuclear and Energy Research (1997) and PhD in Immunology from the Institute of Biomedical Sciences / USP (2002). I am currently a Level VI Scientific Researcher at the Butantan Institute. I develop studies aimed to characterizing the local lesion triggered by toxins isolated from ophidian poisons, such as phospholipases and metalloproteinases. For this study I have experience in techniques of proteins purification by chromatography and characterization of purified proteins. I verified the potential of these toxins in experimental models in vivo (dosage of inflammatory mediators, myotoxic activity, hemorrhagic and edematogenic activity) and also in in vitro models (toxin activities on endothelial cells - toxicity tests, cell migration, wound healing). To understand the mechanism of action, I also use molecular biology techniques, such as real-time PCR to verify the expression of messenger RNA from different inflammatory mediators, induced by different toxins in both in vitro and in vivo models. (Source: Lattes Curriculum)

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