Abstract
Recently we demonstrated that crotoxin (CTX) inhibits, in vitro and in vivo, the process of phagocytosis by neutrophils; this in vivo effect is long lasting, since it can be observed until 14 days after the subcutaneous administration of a single dose of CTX. Furthermore, we demonstrated that this effect is related to the decrease of phosphorylation of tyrosine residues of signaling prote…