CV Lattes
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Universidade São Francisco (USF). Campus Bragança Paulista (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor?s degree in Biological (1995) and in Biomedical Science (1997) at Universidade Estadual de Campinas (UNICAMP, Brazil). Master?s degree in Molecular Biology and Genetics by UNICAMP (1999), and Sandwich Ph.D. at UNICAMP and the University of Southern California (USA) also in Molecular Biology and Genetics (2006). He has experience in the field of Molecular Genetics, with an emphasis on Human and Bacterial Genetics. Currently, leads research projects that focus on understanding the mechanisms that regulate gene expression. (Source: Lattes Curriculum)
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Klebsiella pneumoniae is a Gram-negative bacterium responsible for a wide-range of healthcare-associated infections, particularly in immunocompromised patients. In recent years, the world has been facing the emergence of hypervirulent and multidrug-resistant K. pneumoniae isolates. Moreover, the increasing number of severe community-acquired infections even in healthy individuals has emph…
Klebsiella pneumoniae is a Gram-negative bacterium and considered an opportunistic pathogen. This bacterium has become a global public health problem in recent years due to the emergence of multidrug-resistant and hypervirulent clinical isolates. Polyamines are essential nutrients for cell metabolism, and in many bacteria they are involved in several aspects of pathogenicity, such as biof…
Klebsiella pneumoniae is a Gram-negative opportunistic pathogen. This bacterium has become a worldwide public health problem in recent years, mainly because of the emergence of hypervirulent and multidrug-resistant clinical isolates capable of producing invasive infections not only in immunocompromised patients but also in healthy individuals. Bacteria control gene expression in a coordin…
Iron is an essential nutrient for most microorganisms and it has an important role in cellular metabolism and in the regulation of virulence genes expression in pathogenic bacteria. This regulation is mediated by the transcriptional regulator Fur. Fur forms a complex with ferrous ion and this complex binds to specific sequences, called Fur boxes, located on the promoter region of target g…
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Iron plays an important role on the expression regulation of many virulence genes in pathogenic bacteria. This regulation is mediated by the transcriptional regulator Fur which complexes with iron and binds to specific sequences, named Fur boxes, located in the promoter region of target genes, leading to the transcriptional induction or repression of these genes. Klebsiella pneumoniae is …
Iron has an essencial role on the transcriptional regulation of many genes related to the bacterial pathogenesis, such as those related to biofilm formation and the expression of toxins, fimbriaes, capsules and proteases. The role of iron is mediated by the repressor Fur. Fur, encoded by fur gene, regulates gene expression by binding to DNA regulatory sequences, known as Fur boxes, locate…
Iron is a key nutrient for any microorganism having an important role in cellular metabolism and the expression of numerous virulence factors in pathogenic bacteria. One of the strategies used by bacteria to capture iron is the synthesis and secretion of siderophores, which are molecules that have high affinity to ferric ions. This iron uptake system involves a series of genes whose expre…
| 1 / 1 | Ongoing grants |
| 4 / 4 | Completed research grants |
| 4 / 3 | Completed scholarships in Brazil |
| 9 / 8 | All research grants and scholarships |
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