Clara Lúcia Barbiéri Mestriner

CV Lattes ResearcherID ORCID Google Scholar Citations

Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal)
Birthplace: Brazil

bachelor's at Biomedicina from Universidade Federal de São Paulo (1972), master's at Microbiologia e Imunologia from Universidade Federal de São Paulo (1976) and doctorate at Microbiologia e Imunologia from Universidade Federal de São Paulo (1982). Has experience in Parasitology, focusing on Human Parasite Protozoology, acting on the following subjects: leishmania (l.) chagasi, leishmania l amazonensis, cysteine proteinase, leishmania (l.) amazonensis and leishmania. (Source: Lattes Curriculum)

News published in Agência FAPESP Newsletter about the researcher

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Research grants

Completed (most recent)

Abstract
Our previous data showed that the treatment of canine visceral leishmaniasis (CVL) with the recombinant cysteine proteinase from Leishmania (Leishmania) infantum chagasi, rLdccys1, plus Propionibacterium acnes as adjuvant resulted in immune protective responses and significant reduction of parasite load, control of disease development and increase of survival in treated dogs. Actually all…
New immunochemotherapy schedules for leishmaniasis: association of the recombinant protein Ldcccys1 with allopurinol for treatment of visceral leishmaniasis and with the palladacycle complex DPPE 1.2 for treatment of cutaneous leishmaniasis., AP.R
Abstract
Previous results showed the in vitro and in vivo activity of the palladacycle complex DPPE 1.2 against Leishmania (Leishmania) amazonensis. The treatment of L. (L.) amazonensis-infected BALB/c and C57BL/6 mice with DPPE 1.2 resulted in a significant decrease of lesion size and parasite load at concentrations that are non toxic to the host. There was an increase of CD4+ and CD8+ T lymphocy…
Leishmanicidal activity of palladacycle complexes: in vitro and in vivo inhibitory effect of DPPE 1.1 on Leishmania (Leishmania) amazonensis and evaluation of immune responses in infected mice treated with DPPE 1.2, AP.R
Characterization of an antigen from leishmania amazonensis amastigotes able to elicit protective response in a..., PUB.ART

Scholarships in Brazil

Completed (most recent)

Abstract
Allopurinol is the main drug used for treatment of canine visceral leishmaniasis (CVL), resulting in reduction of the clinical signs of the disease as well as the decrease of parasite burden in treated dogs. However, cases of disease relapse following terminus of allopurinol treatment have been recorded which forces the extension of treatment indefinitely. Previous data from our laborator…
Treatment of visceral leishmaniasis with Alopurinol associated to the recombinant cysteine proteinase from Leishmania (Leishmania) infantum chagasi (rLdccys1)., BP.PD
Abstract
Previous results showed the in vitro and in vivo activity of the palladacycle complex DPPE 1.2 against Leishmania (Leishmania) amazonensis. The treatment of L. (L.) amazonensis-infected BALB/c mice with DPPE 1.2 resulted in a significant decrease of lesion size and parasite load compared to those of untreated animals and no toxicity was observed in treated animals at the concentrations of…
Effect of the treatment with the paladacycle complex DPPE 1.2 associated to the recombinant cysteine proteinase rLdccys1 on Leishmania (Leishmania) amazonensis infection in a murine model, BP.MS
Treatment of murine cutaneous leishmaniasis by the administration of a palladacycle compound associated with a gene encoding a cysteine proteinase from Leishmania (Leishmania) amazonensis (Lacys24)., BP.MS

Virtual Library in numbers * Updated data on August 09, 2025

Total / Available in English

10 / 3	Completed research grants
10 / 3	Completed scholarships in Brazil
20 / 6	All research grants and scholarships

Associated processes

Most frequent collaborators in research granted by FAPESP

Keywords used by the researcher

Biological Sciences Parasitology

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