CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas (FCM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade Estadual de Campinas (1982), master's at Physiology from Universidade Estadual de Campinas (1987) and ph.d. at Pharmacology from Universidade de São Paulo (1991). Has experience in Pharmacology, focusing on General Pharmacology, acting on the following subjects: nitric oxide, inflammation, óxido nítrico, corpus cavernosum and cyclic gmp. (Source: Lattes Curriculum)
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Overview: Diabetes mellitus promotes an array of complications in the body, including micturition (voiding) dysfunction that is referred to as diabetic bladder dysfunction (DBD) or diabetic cystopathy. Voiding dysfunction comprises clinical manifestations which may progress from detrusor smooth muscle overactivity to underactive (hypoactive). During hyperglycemic states there is a marked …
Activation of soluble Guanylate Cyclase (sGC) enzyme expressed in bladder, urethra and prostate smooth muscles induces tissue relaxations by elevating cyclic GMP levels. We have shown that sGC enzyme is found in an oxidized/degraded state in Obesity, Aging and Inflammation (cystitis) conditions, hence producing reduced cGMP levels, which may explain the enhanced contractility of the lower…
Obesity and asthma are prevalent and increasing diseases, and both have significant impact on global public health. Obesity may be an important factor for asthma development, and can even worse a pre-existing asthma. However, studies aiming to examine the mechanisms involved in exacerbation of asthma in obese animals are still scarce, and most have only focused on bronchial hyperresponsiv…
Corpora cavernosa from humans and other mammals relax to transmural stimulation, and these relaxations are sensitive to voltage-gated sodium channel blockers such as tetrodotoxin (TTX). Snakes and lizards are unique among amniote vertebrates in having a bilaterally symmetrical intromitteny penis, known as hemipenises. The transmural stimulation of Crotalus durissus terrificus hemipenises …
(Only some records are available in English at this moment)
Diabetes mellitus (DM) is a metabolic syndrome characterized by high blood glucose levels. One of its complications is diabetic bladder dysfunction (DBD), which affects over 50% of diabetic patients. Problems related to the lower urinary tract in DBD are significant, and although voiding changes are not life-threatening, they can substantially impact individuals' quality of life and contr…
Asthma is a chronic inflammatory disease of the airways that affects more than 300 million people worldwide, thus posing a major threat to global health. In Brazil, asthma is the fourth most common disease in adults and the third in children and young people, resulting in around 160,000 hospitalizations annually and five deaths daily. Asthma is triggered by a complex interaction of geneti…
Diabetes Mellitus (DM) is a metabolic disorder associated with high blood glucose levels. DM leads to several complications in the body, including voiding dysfunction, referred to as diabetic bladder dysfunction (DBD) or diabetic cystopathy, a condition present in more than 50% of patients diagnosed with DM type 1 (DM1) or DM type 2 (DM2), particularly in those in chronic states and not t…
Overview: Asthma is a chronic inflammatory condition of the airways, influenced by genetic and environmental factors. Diabetes Mellitus presents two main categories: Type 1 (DM1) and Type 2 (DM2). In DM2, insulin loses the ability to regulate glucose in muscle cells, resulting in hyperinsulinemia. On the other hand, DM1 is an autoimmune disease characterized by the progressive destruction…
The vascular supply to the bladder is derived mainly from superior and inferior vesical arteries, the latter connected to the internal iliac artery. In animal models of partial obstruction of the iliac arteries and of aging, pelvic arterial insufficiency and detrusor overactivity are observed. The chronicity of the isquemia may progress to bladder underactivity and morphological changes. …
Hormonal decline in women lead to Lower Urinary Tract Symptoms (LUTS) such as voiding frequency, urgency, nocturia, and urinary incontinence that negatively impact the women´s quality of life and social interaction. Hormone replacement therapy with testosterone has been used in postmenopausal women to alleviate certain symptoms of androgen deficiency such as loss of libido and bone and mu…
(Only some records are available in English at this moment)
Reactive-oxygen species (ROS) under optimal production regulate important physiological functions as cell proliferation and differentiation, vascular tone, innate immune response and inflammation. However, in situations where the production of ROS exceeds the cellular antioxidant mechanisms, several vascular and non-vascular-related diseases are installed, including those of the urogenita…
According to a recent NIH report, approximately 8.5% of people worldwide (617 million) are aged 65 and over that will jump to nearly 17% by 2050 (1.6 billion people). In parallel with age, it is expected in the aging male population an increase in lower urinary tract symptoms (LUTS) associated with prostatic inflammation, a condition related with aging that negatively affects men's quali…
The worldwide incidence of obesity has increased dramatically in the past 25 years, and today is considered one of the major public health problems. Recent clinical studies indicate a strong correlation between obesity and genitourinary tract diseases, such as erectile dysfunction and overactive bladder syndrome. The benign prostatic hyperplasia (BPH), which is characterized by an increas…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 21 / 12 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 54 / 23 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 83 / 43 | All research grants and scholarships |
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