CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences, UNESP/Bauru (2002), PhD in Functional and Molecular Biology (Area: Biochemistry) at the Biology Institute/UNICAMP (2007), with a period of sandwich doctorate at the Faculté d'Odontologie Lyon (Université Claude Bernard - Lyon 1/França - 2005/2006) and Postdoctorate in Oral Pathology/Molecular Biology, Dental School/USP (2010-2013). FAPESP Young Researcher of the Department of Biochemistry, Institute of Chemistry/USP (2011-2014). Assistant Professor at Department of Anatomy, Institute of Biomedical Sciences/USP. Postdoctorate in Bichemistry at Kennedy Insttute of Rheumathology, Oxford/UK (2018-2019). Associate Researcher in Professorship ?Darcy Fontoura de Almeida? Advanced Therapies of the Brazilian College of Higher Studies/UFRJ. Head of Laboratory of Extracellular Matrix Biology and Cellular Interaction (LabMec), acting on two lines of research: I) Bone Bioengineering, Biomaterials and Biological Mineralization, and II) Odontogenic tumors and oral cancer. Adviser on Master and PhD. (Source: Lattes Curriculum)
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Our research group has been working on the characterization of osteoblastic differentiation of human dental pulp stem cells (DPSCs or SHEDs) and on new technologies for three-dimensional cell culture, specifically, spheroid models and microfluidic systems. Another aspect is the development of new biomaterials for bone regeneration and their association with these stem cells for the fabric…
Bone grafts are indispensable in orthopedics and dentistry and at a high cost to the health system, but all the methods employed and bone substitutes developed to date do not offer an ideal graft for bone regeneration. Bone Bioengineering recommends an individualized treatment, where the individual's cells are associated with scaffolds/biomaterials to generate a customized bone graft in t…
(Only some records are available in English at this moment)
Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cells (MSCs) that have been extensively researched for the generation of bone grafts based on bone bioengineering, due to their easy obtainability and high osteogenic differentiation potential. Macrophages are highly plastic immune system cells that can be stimulated to polarize to the M1 (pro-inflammatory) or M2 (anti-inflamma…
Bone tissue resident macrophages (osteomacs) are the first cell types recruited to the region of a bone lesion. Through the secretion of pro-inflammatory cytokines (TNF-¿, IL-1 and IL-6), they are able to recruit other cells to act in the regeneration processes of that tissue. The main cells recruited are lymphocytes, monocytes and macrophages. Monocytes can differentiate into M¿ macropha…
During bone repair, the main immune cell involved in this process is the macrophage. Macrophages are responsible for the migration of other cell types, such as endothelial cells and resident stem cells, to the site of injury. The critical calvarial defect is a model to study bone repair and there is no in vitro platform for this type of evaluation. An alternative to mimic in vitro conditi…
(Only some records are available in English at this moment)
It is known that biomimetic grafts are essential for Tissue Engineering in the recovery of damaged tissues. In this regard, three-dimensional cell cultures, such as spheroids, have stood out for their greater regenerative potential compared to disaggregated cells. Among mesenchymal stem cells (MSCs), dental pulp stem cells (DPSCs) are attractive due to their characteristics of multi-diffe…
Regenerative Medicine, specifically the bottom-up approach of Bone Bioengineering, has shown potential in reproducing the cell-cell and cell-extracellular matrix interactions that exist in the tissue environment. With this, three-dimensional (3D) cell culture technologies, such as spheroids, are increasingly being used because they have greater potential for clinical application compared …
The so-called "bottom-up" approach within bone tissue bioengineering has gained more and more attention recently, as, unlike the classic or "top-down" approach, it manages to better recreate three-dimensional cell structures that enable greater cell-cell and cell-extracellular matrix (MEC) interaction, similar to what is found in vivo. Thus, these structures, such as spheroids, are able t…
(Only some records are available in English at this moment)
The cultivation of spheroids and microfluidics are techniques used to create a microenvironment closer to the physiological one in vitro, recreating cell-cells, extracellular matrix-cells interaction and simulating hydrodynamic conditions. Some groups have used microfluidic devices to assess the chemotaxis produced by the spheroid secretome in relation to endothelial cell sprouting. It wa…
Tissue Bioengineering is an approach that aims to reestablish function or replace a specific tissue through the association of cells, biomaterials (scafffolds) and signaling molecules. In this context, mesenchymal stem cells (MSCs) have been extensively studied as well as biomaterials based on collagen. Collagen is the most abundant protein in the extracellular matrix (ECM), its remodelin…