Nobuko Yoshida

• Abstract

  Infection by Trypanosoma cruzi, the etiological agent of Chagas Disease remains a major public health problem in Latin America, home of most people infected. In nonendemic regions like/such as the US, Europe, Japan, and Australia there is growing concern about the risks of transmission by blood transfusion (and organ transplant). Considering that T. cruzi taxon comprises genetically disti…

  Trypanosoma cruzi: intra and interspecific genomic variability and mechanisms of cell invasion/egress, AP.TEM

• Abstract

  Trypanosoma cruzi is the causative agent of Chagas' disease that affects 15-16 million people in America. Vectorial transmission of T. cruzi still occurs in several regions. Migration from endemic areas to developed countries has led to new cases in the US, Europe, Japan and Australia. Since Triatoma infestans has been controlled and transmission by blood transfusion, halted, oral infecti…

  Molecular and cellular biology of the parasitism by Trypanosoma cruzi, AP.TEM

• Abstract

  Trypanosoma cruzi, the etiological agent of Chagas' disease, is a highly relevant microorganism from both medical and biological points of view. Although vectorial transmission is mostly under control in the Southern Cone, T cruzi transmission still prevails in Latin America where 15-16 million people are infected. Outbreaks of acute cases of Chagas' disease by oral infection have been re…

  Molecular studies on Trypanosoma cruzi and its interaction with cells and factors from the host in vitro and in vivo, AP.TEM

(Only some records are available in English at this moment)

• Abstract

  NHE-1 (Na+/H+ exchanger isoform 1), a member of a large family of integral membrane proteins, is found virtually in all tissues and cells of mammals and is necessary for many physiological processes. By regulating intracellular pH, NHE-1 contributes for the actin filament reorganization. The activity of NHE-1 is regulated by extracellular signals mediated by diverse classes of cell surfac…

  The role of host cell Na+/H+ exchanger in invasion by Trypanosoma cruzi metacyclic forms, BP.PD

• Abstract

  Metacyclic trypomastigote forms of Trypanosoma cruzi express surface glycoproteins that interact with the host cell, promoting or negatively modulating their internalization. The mechanisms of invasion by metacyclic forms involving two of these molecules, gp82 and gp90, were partially elucidated. As regards the mucin-like glycoproteins, gp35/50, there is less information. Ggp82 and gp90…

  Mucin-like glycoproteins of Trypanosoma cruzi metacyclic forms: interaction with other surface molecules of the parasite and with the host cell, BP.IC

• Abstract

  Metacyclic trypomastigote forms of Trypanosoma cruzi strains from genetic group TcI are poorly invasive, this property being attributed to the expression. and release at high levels of gp90, the surfasse molecule that functions as a negative modulator of cell invasion. Expression of g90 at low levels is characteristic of invasive strains from genetic group TcVI that use the surface molecu…

  Cell invasion by Trypanosoma cruzi study involving surface molecules gp90 and gp82 of metacyclic forms, BP.PD

(Only some records are available in English at this moment)