Abstract
After cardiac ischemia, there are three stages for tissue replacement of the injured region by repairing tissue rich in collagen - inflammatory, proliferative, and maturation. Myofibroblasts are the cells responsible for the generation of new extracellular matrix (ECM) in the infarcted area and they derive from the activation of cardiac fibroblasts by TGF-² (van den Borne et al., 2010). G…