Abstract
Streptomyces clavuligerus produces various secondary metabolites of therapeutic interest: clavulanic acid, a potent inhibitor of beta-lactamases, and twenty other clavams, several of them with antifungal activity; cephamycin C, a beta-lactam antibiotic used to produce several semi synthetic antibiotics with action against anaerobic bacteria; tunicamycin, a mixture of homologous nucleoside…