CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Camilla is currently an Assistant Professor at the Department of Inorganic Chemistry of the University of Campinas. Her scientific interests are bioinorganic chemistry and medicinal bioinorganic chemistry, particularly the mechanism of metalloproteins and their inhibition by small molecules. In this field, she has studied zinc fingers as therapeutic targets and their inhibition by metal complexes, as the interaction of metallo-beta-lactamases (MBL) with metal complexes. She currently works in the biomimetics development of MBL and SOD and studies the mechanism of action of these enzymes and their inactivation by metals. She studied the design of metal complexes for the treatment of diseases, with a focus on neglected diseases. Recently she was a guest scientist at the Technical University of Munich (TUM). Previously, she developed a postdoctoral project at the Institute of Chemistry at Unicamp in the area of Inorganic Chemistry, Bioinorganic, and Coordination Chemistry. She completed his Ph.D. in the area of Bioinorganic and Chemical Coordination at Unicamp, including a sandwich internship at Virginia Commonwealth University, under the guidance of Dr. Nicholas P. Farrell. She holds a master's degree in Unicamp in Inorganic Chemistry in materials, specifically silicones. She had worked professionally as an Application Engineer providing technical assistance at Dow Corning in Brazil up to 2010. She graduated in Chemistry from Unicamp. (Source: Lattes Curriculum)
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Leishmania parasites cause leishmaniasis, an endemic neglected tropical disease with several clinical manifestations in humans, including visceral (VL) and cutaneous (CL) forms. In Brazil, it has been spreading, leading to an increase in cases in urbanized areas. As a drawback, drug options are limited. For almost a century, antimonials have remained the first line of treatment, even thou…
Leishmania protozoan parasites cause leishmaniasis, a disease with a wide range of clinical manifestations in humans, transmitted by sandfly bites. According to the World Health Organization, it is endemic in 88 countries and affects 12 million people worldwide, being one of the most neglected tropical diseases. The control of leishmaniasis is puzzling, particularly in Brazil, where it ha…
In this project, several metal-based compounds will be systematically developed and evaluated to selectively target zinc finger domains (ZF). Based on the recent report that organometallic gold(III) cyclometalated compounds can selectively target PARP-1 ZF domains in a combination of Cys3His (PARP-1) with Cys2His2 (commonly found in transcription factor), we propose to rationalize the sel…
The microbial resistance is a challenge that deserves the high attention of the scientific community. Among the bacterial resistance mechanisms, the most concerning is the emergence of novel types of hydrolytic enzymes, responsible for the inactivation of the beta-lactam antibiotics, the beta-lactamases, in special metallo-beta-lactamases. Our research group demonstrated that phosphinegol…
(Only some records are available in English at this moment)
Leishmania protozoan parasites cause leishmaniasis, a disease with a range of clinical manifestations in humans, transmitted by sandfly bites. According to the World Health Organization, it is endemic in 88 countries and affects 12 million people worldwide, classified as one of the most neglected tropical diseases. Leishmaniasis control is puzzling, particularly in Brazil, where it has be…
Leishmaniasis is a parasitic disease caused by Leishmania spp., a kinetoplastid protozoa, transmitted to mammals through the bite of a female sandfly. According to the World Health Organization, it is endemic in 88 countries and affects 12 million people worldwide, and it is classified as one of the most neglected tropical diseases. Treatment options have high toxicity, resistance problem…
Leishmania protozoan parasites cause leishmaniasis, a disease with a range of clinical manifestations in humans, transmitted by sandfly bites. According to the World Health Organization, it is endemic in 88 countries and affects 12 million people worldwide, classified as one of the most neglected tropical diseases. Leishmaniasis control is puzzling, particularly in Brazil, where it has be…
(Only some records are available in English at this moment)
Drug-like properties are molecular properties that can be used as qualitative parameters to define if a compound has the potential to be a drug. Among the properties, we can mention lipophilicity, interaction with biomolecules, the number of polar chemical groups, or able to engage in hydrogen bonding. Metallodrugs are molecules that possess at least one metal in the chemical structure an…
The introduction of highly active anti-retroviral therapy (HAART) in the middle of 1990 changed radically the morbidity and mortality rates of the patients infected by the human immunodeficiency virus (HIV). However, HAART is not curative, being a lifelong therapy, causing different side effects and generating drug resistant mutants. Therefore the search for new anti-retroviral drugs is e…
Metal-based drugs, particularly organometallic compounds featuring N-heterocyclic carbenes (NHCs), are crucial in medicinal chemistry for combating diseases. Recent research highlights the significant potential of symmetric arylated NHC gold(I) and copper(I) complexes, with ongoing investigations into their mechanisms involving reactive oxygen species (ROS) and reactive nitrogen species (…
| 1 / 1 | Ongoing grants |
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| 4 / 4 | Ongoing scholarships in Brazil |
| 4 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 14 / 13 | All research grants and scholarships |
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