Abstract
Chronic allograft nephropathy (CAN) is the major barrier to long-term graft survival. Kidney graft function is intimal related to the degree of the tubulointerstitial fibrosis (TIF). Recent studies suggest that some interstitial myofibroblasts might be derived from kidney tubular epithelial cells that have undergone epithelial-to-mesenchymal transdifferentiation (EMT). The additional effe…