CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Assis. Faculdade de Ciências e Letras (FCL-ASSIS) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (2001), m.sc. at Applied Imunology from Universidade de São Paulo (2004), ph.d. at Imunologia Básica e Aplicada from Faculdade de Medicina de Ribeirão Preto (2007) and ph.d. at Fisiologia e Fisiopatologia da Resposta Imune from Universite de Paris VI (Pierre et Marie Curie) (2007). Has experience in Imunologia, focusing on Inflamação, acting on the following subjects: heparina, estrutura secundária, poli-l-lisina, força iônica and mastoparanos. (Source: Lattes Curriculum)
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Cancer and infectious diseases present complex and limited treatments, which, despite advances in research, continue to cause thousands of victims worldwide. The use of gold nanoparticles (NPOs) presents itself as an alternative to conventional treatments, but their aggregation in biological fluids has still been a major obstacle to their biomedical application. Our group demonstrated tha…
Respiratory Syncytial Virus (hRSV) is the major etiologic agent of acute lower respiratory tract infections, resulting in more than 3 million very severe cases of bronchiolitis throughout the year. During infection, leukocytes are massively recruited to the infectious site where they secrete cytokines and other inflammatory mediators. About 70% of these cells are neutrophils that, in addi…
Worldwide, it is estimated 12 million cases of severe lower respiratory tract infection, including respiratory syncytial virus (HRSV) which contributes to the development of bronchiolitis, pneumonia, obstructive pulmonary infections. Neutrophils are the predominant phagocytes in these infections, contributing to the elimination of pathogens by classical microbicidal mechanisms. Neutrophil…
(Only some records are available in English at this moment)
The Human Orthopneumovirus, also known as Human Respiratory Syncytial Virus, is responsible for several hospital admissions of children, the elderly and immunosuppressed people due to complications of the lower respiratory tract. Currently, there is no specific and financially accessible treatment. Furthermore, available vaccines don't cover all risk groups. Our research group has investi…
Cancer and infectious diseases present complex and limited treatments that, despite advances in research, continue to cause thousands of victims worldwide. The use of gold nanoparticles (AuNPs) has emerged as an alternative to conventional treatments. The interaction between AuNPs and cells of the immune system, particularly neutrophils, has been of great interest. Neutrophils act (or may…
The Human Respiratory Syncytial Virus (hRSV) is a common cause of severe respiratory infections, especially in children, the elderly, and immunocompromised individuals, with high rates of morbidity and mortality. Current treatments, such as Ribavirin and monoclonal antibodies, are limited. The AREXVY vaccine was approved in 2023 but is restricted to the elderly, leaving many vulnerable in…
The Human Respiratory Syncytial Virus (hRSV) is recognized as a frequent cause of serious respiratory infections, especially among children, the elderly and immunosuppressed individuals, presenting high rates of morbidity and mortality. Although treatments and vaccines have been developed, their applications are limited and still leave part of the vulnerable population unprotected. Our re…
The Orthopneumovirus, commonly called Human Respiratory Syncytial Virus (hRSV), is one of the main etiological agents of lower respiratory tract diseases and is frequently responsible for the hospitalization and death of children and the elderly. So far, treatments are only palliative and the available vaccines do not cover all risk groups. Plant-derived biomolecules are vital research ta…
In this scientific initiation project (CI), the phenolic compounds sophoricoside and pinobanksin will be evaluated for their ability to interact with lipid membranes derived from human (A375) and oropharyngeal (HEp-2) melanoma. The compounds were selected by an artificial intelligence (AI) in order to predict flavonoids that have the ability to inhibit the human respiratory syncytial viru…
(Only some records are available in English at this moment)
The Human Respiratory Syncytial Virus (hRSV) is one of the leading causes of severe respiratory infections in children, the elderly, and immunocompromised individuals, resulting in high morbidity and mortality rates. Current prophylactic and therapeutic options (Ribavirin, monoclonal antibodies, and vaccines) remain limited in terms of efficacy, accessibility, and coverage for at-risk gro…
According to the United Nations Organization (UNO), Brazil stands out as the largest agricultural exporter worldwide, and to keep up this production, it has been the country that most applies pesticides in the world. Although the increase of the crop production, the use of pesticides also impacts the human health and environment. The Assis mesoregion is prominent in the production of suga…
Respiratory Syncytial Virus (hRSV) is the main etiologic agent of acute viral infections of the lower respiratory tract, against which there is still no financially accessible specific treatment or approved vaccine. In the lung tissue of the infected patient, there is an intense accumulation of neutrophils. In the sustained presence of external stimuli (microorganisms, parasites and infla…
Neutrophils Extracellular Traps (NETs) are released from activated neutrophils during inflammatory process. They capture and/or kill pathogens but they also are cytotoxic to pulmonary cells. Histones, elastase e myeloperoxidase are present in the NETs and they have been described as responsible proteins for the tissue damage induced by NETs. Our preliminary results demonstrated that flavo…
| 1 / 1 | Ongoing grants |
| 5 / 5 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 14 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 27 / 22 | All research grants and scholarships |
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