Abstract
Sirtuins are members of a family of proteins that present NAD+-dependent deacetilase activity and are involved in many biological functions. A member of this family, named Sir2 Related Protein 1 (Sir2RP1), has already been characterized in some Leishmania and along the FAPESP project 2008/58617-5, we identified and characterized the L. amazonensis Sir2RP1 ortholog (LaSir2RP1) (Fessel et a…