Associate Professor 3 at the USP School of Medicine. Head of the Interdisciplinary Neuromodulation Service and Co-Director of the ECT Service of the HC-FMUSP Institute of Psychiatry. Member of the Innovation Committee of HC-FMUSP (INOVAHC). Full Advisor of the PPGs in Medical Sciences and Psychiatry at FMUSP. Appointed by the Web of Science / Clarivate Analytics as one of the most cited researchers in the world in the years 2019, 2020, 2021 and 2022. Prof. Brunoni has more than 365 articles published in indexed journals, with more than 15400 citations and an H index of 57 (Scopus). Prof. Brunoni has publications as 1st or last author in prominent journals such as the New England Journal of Medicine, JAMA Psychiatry, Molecular Psychiatry, Lancet Psychiatry and American Journal of Psychiatry. He has an extensive international network of collaborators, including centers at Harvard University, Oxford University, University of Munich, University of New South Wales, University of Toronto, UTHealth in Texas, Ghent University, and the University of Coimbra.Education: MBA by USP/Esalq (2021-2023). Habilitation Degree at the Department of Psychiatry at the Faculty of Medicine of USP (2017). Newton Advanced Fellowship, in partnership with Oxford University (2021-2023). Visiting Professor at the University of Munich (April-2017/October-2018) with an experienced researcher grant from CAPES / Alexander Von Humboldt Foundation. PhD in Neuroscience and Behavior at the Institute of Psychology at USP (2010-2012), with a Sandwich Doctorate at Harvard Medical School (Boston, USA). Graduation in Medicine (2004), Residencies in Internal Medicine (2005-2007) and Psychiatry (2007-2010) from the Faculty of Medicine of USP.Lines of investigation: depression and mood disorders, non-invasive neuromodulation in the treatment of mental disorders. (Source: Lattes Curriculum)
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About 30% of patients with depression do not respond adequately to pharmacological treatments. While antidepressants are widely used, they show modest efficacy and are often accompanied by side effects. Psychotherapy, on the other hand, faces a shortage of qualified professionals, and electroconvulsive therapy, although effective, can cause cognitive effects and is not easily accessible. …
Decades of neuroscience research have identified potential biomarkers involved in neuropsychiatric disorders, with those that reflect brain functioning - characterized primarily by functional neuroimaging and electrophysiology - particularly promising. However, the use of these findings in clinical trials is challenging. Non-invasive neuromodulation of neural circuits, performed by means …
Major Depressive Disorder (MDD) is a condition with high prevalence and morbidity worldwide. Treatments have limited efficacy and are curbed by adverse effects (Pharmacotherapy) or availability and costs (psychotherapy). Thus, developing novel interventions is tremendously relevant and can bring major gains in psychiatric care. Non-Implantable Neuromodulatory (NIN) approaches such as tran…
Non-invasive brain stimulation approaches have been increasingly used to target the prefrontal cortex and to induce activity changes in brain networks. New protocols within the field of neurostimulation suggest a combination of distinct non-invasive brain stimulation techniques that are based on different approaches to maximize required changes in brain activity. However - as the effects …
Dr. Mantovani will serve as Co-Investigator in our research studies testing the clinical and neurobiological effects of Transcranial Direct Current Stimulation (tDCS) in Major Depressive Disorder (Young Investigator FAPESP grant 2012/20911-5) and Obsessive Compulsive Disorder (ongoing research project at the Institute of Psychiatry). Moreover, Dr. Mantovani will teach graduate and post-gr…
(Only some records are available in English at this moment)
Non-invasive brain stimulation therapies, such as transcranial magnetic stimulation (TMS) and transcranial electrical current stimulation (tES), are promising alternatives for treating depression. In recent years, a variant of TMS, intermittent theta-burst stimulation (iTBS) over the prefrontal cortex, has gained prominence. In this scenario, individualized neuromodulation strategies, aim…
Cognitive alterations, both cold (emotion-independent) and hot (emotion-dependent), are common in depressive episodes and may persist even after treatment. The higher the number of previous episodes, the worse the recovery. This way, searching for more effective treatment methods with lower relapse rates and cognitive impacts is necessary. Objective: This study will investigate cognitive …
(Only some records are available in English at this moment)
Psychiatric disorders are important causes of disability around the world. When occur in children and adolescents, frequently are late diagnosed and suboptimal treated, culminating in a chronification of the disease. Treatment options vary according to the disorder and range from exclusively non-pharmacological approaches - as in the case of autism spectrum disorder - to a combined therap…
(Only some records are available in English at this moment)
Major depressive disorder (MDD) is a prevalent mental disorder characterized by persistent feelings of sadness, loss of interest or pleasure, and various cognitive, emotional, and physical symptoms. The impact of depression extends beyond individuals to their families, communities, and society at large. Treating depression with medication presents challenges related to treatment resistanc…
Electroconvulsive therapy (ECT) is the most effective treatment for major depression disorder (MDD), even when compared to simulated ECT, repetitive transcranial magnetic stimulation (rTMS) and pharmacotherapy, the first line treatment for MDD. Although its clinical effects are well known, its neurobiological mechanisms underpinning the striking antidepressant effects remain poorly elucid…
Major Depressive Disorder (MDD) causes important disabilities. Antidepressant drugs are the MDD most frequent treatment, but other ideal options are needed, and transcranial direct current stimulation (tDCS) is a promising one. TDCS is a non-invasive stimulation technique that injects low-intensity electrical current via electrodes located on the scalp, acting to facilitate or inhibit syn…
| 3 / 3 | Ongoing grants |
| 4 / 4 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 39 / 31 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 54 / 46 | All research grants and scholarships |
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