Dentist graduated from the São Paulo State University Júlio de Mesquita Filho (UNESP), Araraquara campus, in 2002, with a Masters degree (2005) and a Ph.D. (2009) in Pharmacology from the Federal University of São Paulo (UNIFESP). During her doctoral studies, she completed a research internship at the University of Virginia (2007) and, more recently, a sabbatical at the Seattle Childrens Research Institute (2024). She is currently an Associate Professor (level 3) at the Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo (USP).In the field of academic administration, she serves as Chair of the Department of Pharmacology at ICB-USP, and has previously held positions as Chair and Vice-Chair of the Faculty Committee (20212023) and as Coordinator and Vice-Coordinator of the Graduate Program in Pharmacology (20172023). She has also held roles in scientific societies, having served as Treasurer of the Brazilian Society of Physiology (20152016), Treasurer (20172021), and First Secretary (20212023) of the Federation of Experimental Biology Societies (FeSBE).Her research focuses on the regulation of breathing by the mammalian central nervous system, with an emphasis on identifying neuronal networks in rodents using electrophysiological and neuroanatomical approaches. She also investigates how these networks are altered in experimental models of neurodegenerative diseases, particularly Parkinsons disease, exploring mechanisms related to neuroinflammation, sexual dimorphism, and sleep disturbances. Beyond her academic career, she is the mother of Luísa (17 years old) and Laura (13 years old). (Source: Lattes Curriculum)
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Parkinson's disease (PD) is a neurodegenerative disease characterized by the death of dopaminergic neurons in the compact portion of the Substantia Nigra (SNc) which promotes the classic motor symptoms that are related to movement: rest tremor, rigidity, bradykinesia and postural instability. Although these symptoms are responsible for the diagnosis of the disease and are the therapeutic …
Parkinson's disease (PD) is a neurodegenerative disease characterized by the death of dopaminergic neurons in the compact portion of the Substantia Nigra (SNc) which promotes the classic motor symptoms that are related to movement: rest tremor, rigidity, bradykinesia and postural instability. Although these symptoms are responsible for the diagnosis of the disease and are the therapeutic …
O evento será realizado em um dia, com início às 9 da manhã e fim às 18:30. O programa será composto por 15 apresentações orais (20 minutos) de pesquisadores do Brasil e estrangeiros. Além disso, o programa também será composto por uma sessão de pôsteres de 2 horas. (AU)
Parkinson's disease (PD) is a neurodegenerative disease that affects approximately 1% of the population over 60 years. It is characterized by classic motor symptoms such as bradykinesia, tremors and postural instability. In addition, there are also autonomic non-motor symptoms (constipation, orthostatic hypotension), cognitive and respiratory changes that greatly impair patients' quality …
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra compacta (SNc). The main motor symptoms are tremor at rest, bradykinesia, classic rigidity and postural instability. However, we can observe non-motor symptoms as neuropsychiatric, sleep and breathing disorders. Neuroanatomical studies show that the nu…
(Only some records are available in English at this moment)
Parkinson's Disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons and the aggregation of the protein alpha-synuclein. Additionally, non-neuronal cells, such as microglia, astrocytes, and oligodendrocytes, also seem to be involved in the disease pathophysiology. It should be mentioned that there is no cure for PD yet, and only limited ph…
The etiology of Parkinson's disease (PD) is multifactorial, and current treatments are only partially effective, as the symptoms are not solely due to reduced dopamine release (Albers et al., 2017; Besedovsky et al., 2019; Chahine et al., 2017). Sleep disturbances are among the main symptoms that precede the classical motor signs of PD and include: dysregulation of the sleep-wake cycle, i…
The influence of sex hormones on breathing is still not fully understood, especially in multifactorial pathological contexts such as Parkinson's disease (PD). Efforts should be made to study these phenomena, as they directly affect patient prognosis and survival, with the aim of developing the best possible treatments. In this context, the objectives proposed in this direct PhD project in…
(Only some records are available in English at this moment)
Parkinson's Disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the Substantia Nigra (SN) and the presence of classic motor symptoms. However, in PD, there are also other symptoms, and among them, we have respiratory changes that result from degeneration occurring in neural groups involved in the control of breathing, such as the preBötzinger C…
Parkinson's Disease (PD) is a neurodegenerative disorder that is associated with the loss of dopaminergic neurons in the substantia nigra compacta (SNpc) leading to a reduction of dopamine in the nigrostriatal pathway. The motor symptoms are characterized by tremor and bradykinesia while the non-classic symptoms include cognitive deficits, sleep disorders, sensorial dysfunction and breath…
Parkinson's Disease (PD) is a neurodegenerative disorder characterized by the accumulation of intracellular protein and the progressive and irreversible loss of dopaminergic neurons of the substantia nigra pars compacta (SNpc), which leads to a decrease in the dopamine in the striatum. The deficiency of this neurotransmitter leads to the classic motor symptoms of PD, such as tremors and p…
(Only some records are available in English at this moment)
Parkinson's disease (PD) is a neurodegenerative disorder characterized by classic motor symptoms, such as tremors and postural instability. In addition, PD can present with non-classical symptoms, which may include respiratory deficits, one of the leading causes of death in affected individuals. Previous studies have shown that the respiratory deficits observed in PD may be linked to dama…
Parkinson's disease (PD) is a neurodegenerative disease characterized by the death of dopaminergic neurons in the compact portion of the Substantia Nigra (SNc) which promotes the classic motor symptoms that are related to movement: rest tremor, rigidity, bradykinesia and postural instability. Although these symptoms are responsible for the diagnosis of the disease and are the therapeutic …
Parkinson´s disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra compacta (SNpc). We can observe non-motor symptoms as neuropsychiatric, sleep and breathing disorders. It was noticed in post-mortem humans brains and in 6-hydroxydopamine (6-OHDA) rat model of PD a significant reduction of neurokinin 1 receptor (NK1r)…
(Only some records are available in English at this moment)
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