Abstract
Trypanosoma brucei is the parasite that causes sleep disease in Africa and is an excellent model for biosynthesis and metabolism of glycosylphosphatidylinositol (GPI) anchors. Blood forms of the parasite express a GPP-specific phospholipase C (GPl-PLC), capable of releasing its variant surface glycoprotein (VSG) since it is anchored by GPI. The shape of this parasite that multiplies in th…