bachelor's at Farmácia e Bioquímica from Universidade Federal de Santa Catarina (1981), master's at Pharmacy from Universidade de São Paulo (1990) and doctorate at Parasitology from Universidade de São Paulo (1998). Has experience in Microbiology, focusing on Microbiology, acting on the following subjects: detecção, e. coli diarreiogênica, epec, imunodiagnóstico and anticorpos monoclonais. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Shiga toxin-producing Escherichia coli (STEC) and its subgroup enterohemorrhagic E. coli (EHEC), one of the six pathotypes of diarrheagenic E. coli, is a concern for human health, as it is associated with outbreaks of infections and food poisoning from ingesting contaminated food or water, particularly undercooked meats, raw vegetables and milk. These bacteria produce the most potent cyto…
Escherichia coli are characterized by harboring both commensal and / or symbiotic strains, as well as strains that are pathogenic to the intestinal and extraintestinal sites of humans and warm-blooded animals. This plurality of behavior is due, on the one hand, to the fact that most of its virulence determinants are encoded in mobile genetic elements and, on the other hand, the extreme pe…
Antibodies are produced by the immune response to foreign antigens, however this response is limited to an individual's immune system, and for this reason, synthetic antibodies enable applications beyond the extent of natural antibodies. Recombinant antibodies can be obtained from synthetic antibody libraries through the use of several technologies, among them phage display technology (Zh…
(Only some records are available in English at this moment)
Toxin-antitoxin systems are genetic modules composed of a labile antitoxin that inhibits a stable toxin and are associated with some physiological processes of bacteria, such as the formation of persistent cells, biofilm formation, protection against bacteriophages and responses to stressful environments. In these modules, the toxin is related to the inhibition of physiological processes …
Toxin-antitoxin (TA) systems are genetic modules that are widespread in prokaryotes and archaea. On the chromosome, these systems may be involved in several virulence factors of pathogenic bacteria. In E. coli K12, 36 TA systems have been described, of which type II is the most abundant and studied. Within the scope of E. coli that cause diarrhea, the STEC pathotype stands out as one of t…
Shiga toxins (Stx1 and Stx2) produced by Shiga toxin-producing Escherichia coli (STEC) are potent AB5 type cytotoxins. This toxin family is characterized by a structure formed by two characteristic functional domains: the B subunit forms a pentamer responsible to bind to its receptor, GB3; while the A subunit has a catalytic action, whose mechanism is N-glycosidase, removing an adenine fr…
Diarrhea causes approximately 800,000 deaths per year among children under five years of age, with diarrheogenic Escherichia coli strains accounting for 30-40% of cases of severe diarrhea in developing countries, including enteropathogenic E. coli (EPEC) and enterohemorrhagic (EHEC) are often associated with cases of the disease. EPEC and EHEC induce an attaching / effacing lesion (A / E …
(Only some records are available in English at this moment)
Uropathogenic Escherichia coli (UPEC) are the main cause of urinary tract infection (UTI). Among the virulence factors produced by UPEC, alpha-hemolysin (HlyA) and cytotoxic necrotizing factor 1 (CNF1) stand out. These toxins become good targets for diagnosis and therapeutic interventions, once there is a need for a rapid and sensitive diagnostic method, as well as new therapies, which al…
Shiga toxin-producing Escherichia coli is responsible for hemorrhagic colitis and hemolytic-uremic syndrome, which aggravates the condition of the infected patients. The diagnosis of this pathogen is not included in routine laboratories in developing countries. The development of tools for detecting these toxins becomes very relevant to their diagnosis. Antibodies have proven to be an exc…
| 2 / 2 | Ongoing research grants |
| 27 / 14 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 34 / 18 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 67 / 38 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID