Ana Maria de Oliveira

• Abstract

  Angiotensin II (Ang II) evokes pro-atherogenic effects by activating AT1 receptors, which subsequently releases TNF-±, that activates NAD(P)H oxidase and generates superoxide (O2-) and hydrogen peroxide (H2O2), a well-known COX2 inductor. In turn, COX2 also generates reactive oxygen species (ROS), that contribute to the dyslipidemic vascular dysfunction. Despite the atherogenic effects fr…

  Consequences of dyslipidemia on the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - mas axes from the angiotensinergic system in aorta from young and adult LDLr knockout mice, AP.R
• Maturation and ageing related differences in the responsiveness to alpha 1-adrenoceptor stimulation in rat carotids arteries., AR.EXT

• Abstract

  The adipokine chemerin is constitutive, which is extremely important to understand the biological effects in non-pathological conditions, although in obesity is observed where hypertrophy and hyperplasia of adipocytes and an increase in synthesis and release of adipokines, with this condition associated with insulin resistance and endothelial dysfunction. Hardly know the effects of adipok…

  Effects of the adipokine Chemerin on the Responsiveness to Insulin Mesenteric Arteries of Mice, BP.DR

• Abstract

  By activating AT1 receptors, angiotensin II (Ang II) induces the endothelial release of tumor necrosis factor-± (TNF-±), which evokes pro-atherogenic effects mediated by NAD(P)H oxidase-derived superoxide anion (O2-). Despite the pro-atherogenic effects mediated by AT1 receptors, the ACE2 - Angiotensin-(1-7) [Ang-(1-7)] - Mas axis evokes vaso-and atheroprotective effects. In fact, the chr…

  Study of the consequences of the inflammatory process induced by AT1 receptors during atherosclerosis on the ACE2 - angiotensin-(1-7) - Mas axis in mouse aorta and the involvement of Mas receptors in the vaso- and atheroprotective effects of losartan, BP.PD

• Abstract

  Obesity is associated with dysfunction of the white adipose tissue, with an increased release of pro-inflammatory cytokines. This condition is also associated with insulin resistance and endothelial dysfunction. The mechanisms by which cytokines released by the adipose tissue interfere with vascular function or with the modulation of vascular function in obesity are not yet fully understo…

  Effects of the adipokine chemerin on the vascular reactivity: analysis in rat aorta, BP.MS

(Only some records are available in English at this moment)

• Abstract

  The adipose tissue produces many adipokines, including chemerin, a chemoattractant molecule that mediates its effect through a G protein-coupled receptor, ChemR23. Chemerin has been linked to vascular endothelial dysfunction, inflammation and insulin resistance, key contributors to several disease processes, including obesity, diabetes and arterial hypertension. Considering that db/db mic…

  Role of chemerin/ChemR23 system on insulin signalling in adipocytes and arteries of db/db mice, BE.EP.DR