Abstract
Aggregatibacter actinomycetemcomitans is an important periodontal pathogen associated with periodontal diseases and extra-oral infections as endocarditis. A. actinomycetemcomitans has the ability to adhere and invade and epithelial cells, and to survive and perpetuate in infected tissues, produces many virulence factors, including the cytolethal distending toxin (Cdt). In our previous res…