Abstract
Mucopolysaccharidoses (MPSs) are rare lysosomal storage diseases. MPSs are hereditary, progressive, chronic, multisystemic and there are many degrees of severity. They are caused by low or absent activity of enzymes that metabolize the glycosaminoglycans (GAGs). This enzymatic inefficiency leads to accumulation of GAGs partially or not degraded within the lysosomes. In consequence, there …