CV Lattes
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ORCID
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Denise Morais da Fonseca in research grants and scholarships supported by FAPESP.
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Bacterias contra enfermedades |
| Bacteria against disease |
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
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Mucosal tissues are endowed with a specialized immune system with specific effector mechanisms designed to respond to the enormous range of regional challenges while maintaining tissue homeostasis. In this sense, specialized cells and immune mediators are found in each mucosal tissue. Classically, subtypes of dendritic cells, T lymphocytes, and antibody-producing B cells are differently r…
The immune system deals with highly diverse infectious challenges in a manner that both promotes the control of invading agents and restores tissue homeostasis. At barrier tissues, sites of constant microbial exposure, tissue-specific immunity requires defined structural components that have immunologic and neuroendocrine detectors providing signal for the spatial segregation from the mic…
The intestinal mucosa is the largest area of the body exposed to the external environment and to antigens derived from the commensal microbiota or from the diet. At the same time that it controls the nutrient absorption, the gut mucosa, together with the associated lymphoid and adipose tissues, has immunological and neuroendocrine sensors that integrate signs of changes in homeostasis, el…
The gastrointestinal tract houses several commensal microorganisms that actively participate in the modulation of the host's metabolism. In addition to the microbiota, this tissue receives several daily antigens from the diet, so a highly specialized immune system is needed, which allows the host to tolerate the microbiota and diet antigens and to develop responses against potential patho…
Inflammatory bowel diseases (IBD) affect millions of people worldwide, representing a substantial public health challenge. Several mechanisms have been studied to explain the etiology of such diseases and help in their management, including infectious diseases that affect gut homeostasis. Our group have shown that, after the resolution of defined types of acute intestinal infection, there…
This fellowship is being requested for a scientific initiation student to collaborate directly for the conclusion of a subproject linked to JP assistance. The main goal of this project is to evaluate the contribution of the anti-inflammatory cholinergic pathway in the inflammation of adipose tissue and the development of diet-induced metabolic syndrome. Our previous date points out for th…
The barrier tissues, such as the gut, lung and skin, are highly complex environments. The gut, in particular, is the largest organ of the body exposed to antigens, including: infectious agents, microbiota and dietary components, which influence tissue homeostasis. Therefore, the intestinal mucosa-associated immune system, is endowed with a complex cellular network and highly regulated mec…
(Only some records are available in English at this moment)
Recent studies point to the hypothesis of communication between the intestinal and pulmonary mucosa through mediators from the gastrointestinal (GI) tract. These mediators can interfere with the homeostasis of distant tissues, such as the lung; conversely, changes in the lung microenvironment can regulate the homeostasis of the GI tract. However, the function of the mucosal-associated imm…
Mucosal tissues are endowed with a specialized immune system designed to respond to an enormous range of regional challenges while maintaining tissue homeostasis. Our research group has been working to understand and integrate the mechanisms that act not only in maintaining tissue homeostasis but also in the communication between barrier tissues, such as the intestine and the lung. The co…
In recent years, we have experienced a widespread of obesity affecting population at different ages worldwide. It has been shown that obesity is highly associated to the development of systemic and adipose tissue chronic inflammation. As a consequence of this chronic inflammation, secondary pathologies such as diabetes, cardiovascular diseases and metabolic disorders may develop. Recent s…
The impairment of mechanisms involved in the regulation of immune responses in sites of high antigenic exposure, such as the intestinal mucosa, leads to the development of chronic inflammatory bowel diseases (IBD). The pathogenesis of IBDs is closely related to the breakdown of tolerance to intestinal microflora, an event that also occurs after infection with Toxoplasma gondii. This infec…
| 1 / 1 | Ongoing research grants |
| 1 / 1 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 14 / 12 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 22 / 20 | All research grants and scholarships |
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