CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
BSc from the Federal University of São Paulo - UNIFESP (2004). PhD in Immunology and Parasitology at the Federal University of São Paulo (2009). Post-doctoral studies at the Insitut Curie, Paris (2010-2014). Since 2014 I work as assistant professor in the Department of Immunology, Institute for Biomedical Sciences at the University of São Paulo (ICB/USP). I have worked in vaccinology, especially vaccines against parasitic diseases (Chagas' disease) and stimulation of the CD8 T cell response. Currently, my interest lies in cell biology of immune system cells, especially in proteins associated to the cytoskeleton and their roles in both pathogenic and physiological conditions. I also work with experimental infection with the HIV virus of primary human cells and cell lineages (macrophages, dendritic cells and CD4+ T lymphocytes). (Source: Lattes Curriculum)
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Myosins are actin-dependent motor proteins. Cells of the immune system express a range of different myosins that have a role in processes like endo- and exocytosis, migration and cell division. The participation of myosins in the regulation and signaling by innate immunity cytoplasmic receptors, however, is unknown. The unconventional myosin IXB is highly expressed in leukocytes and, in a…
HIV-1 debilitates the immune system especially due to its ability to infect CD4+ T lymphocytes. However, other cells of the immune system also interact with the virus and are important in the course of infection. That is the case of macrophages and dendritic cells. Macrophages can be directly infected by HIV-1, are involved in AIDS-associated dementia, and are considered viral reservoirs.…
CD4 T lymphocytes are the main target cells of HIV-1. However, myeloid cells can also become infected by HIV-1 through interaction with CD4/CCR5 receptors. Macrophages can survive infected for long periods and present compartments containing viruses (VCCs), where HIV-1 accumulates and remains infective. For these reasons, macrophages may be potential viral reservoirs. On the other hand, d…
Macrophages are considered important reservoirs for the HIV-1 virus. Several pieces of evidence point to the participation of the actin cytoskeleton in the replication of HIV-1 in macrophages. In spite of that, not much is known about motor proteins, including myosins, in the HIV-1 cycle. In order to implement the study of the participation of cellular myosins in HIV replication, they wil…
Trans-infection is a process through which uninfected dendritic cells (DCs) carry and transmit the virus HIV-1 to CD4 T cells. Several pieces of evidence point to an important role of the actin network in this process, but the motor proteins involved in trans-infection have not yet been described. This project intends to describe the myosins involved in HIV-1 trans-infection by DCs throug…
| 1 / 1 | Ongoing grants |
| 1 / 1 | Completed research grants |
| 5 / 3 | Completed scholarships in Brazil |
| 7 / 5 | All research grants and scholarships |
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