CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biomedical Sciences in the Federal University of São Paulo (2004) and Ph.D. in Microbiology and Immunology, Federal University of São Paulo (2009). Did a post-doctoral training at the Institut Pasteur in Paris, France. He is currently assistant professor at the Department of Parasitology, University of São Paulo. Has experience in immunology with emphasis on vaccine development, in molecular genetics of Plasmodium oriented for generation of recombinant parasites, and in the field of cell biology of Plasmodium, focused on host cell invasion and transmission. (Source: Lattes Curriculum)
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A Reunião Nacional de Malária contará com a realização de 14 mesas temáticas, que ocorrerão ao longo de quatro dias de evento. Cada mesa será composta por três ou quatro palestrantes e dois debatedores, promovendo um espaço de apresentação e discussão científica qualificada. As palestras terão duração de 20 minutos, sendo seguidas por um momento de debate conduzido pelos debatedores, com …
Malaria drug discovery and vaccine development is traditionally focused on studies using asexual blood stages maintained in laboratory cultures. The biology of the sexual stages (gametocytes and gametes) is very different from that of the asexual stages, and few drugs currently in use to treat Malaria are capable of killing the gametocytes, preventing parasite transmission from humans to …
Hemoparasites are parasites that multiply inside the bloodstream. Plasmodium, the causative agent of malaria in mammals, and Babesia, the causative agent of babesiosis, are hemoparasites belonging to the phylum apicomplexa that invade and multiply inside erythrocytes. These parasites are a huge problem for human and animal health. Plasmodium is the most important human parasite with an es…
Invasion of host cells by Plasmodium zoites is a complex process and involves multiple proteins and protein complexes that are targets for the development of malaria vaccines. In P. falciparum, a complex (PCRCR) composed of P. falciparum thrombospondin-related apical merozoite protein (PTRAMP), cysteine-rich small secreted protein (PfCSS), PfRh5-interacting protein (PfRipr), cysteine-rich…
Malaria is a serious public health problem. Estimates from WHO show that there were approximately 241 million cases of malaria and 627,000 deaths due to malaria in 2020. Historically, Plasmodium antigen characterization has focused on blood stage antigens expressed by the merozoite forms or pre-erythocitic antigens expressed by the sporozoites, since these are the infectious stages for hu…
Through advances in genomics, proteomics and transcriptomics, currently studies analyzing these tools in search of new targets for potential drugs and vaccines are increasingly present in academia. Important targets to be sought are proteins involved in the life cycle of the protozoan Plasmodium, the causative agent of malaria, for potential vaccine formulations, such as for the vaccine s…
Malaria is a parasitic disease that has afflicted humankind for centuries, and even today it causes thousands of deaths annually, especially in underdeveloped countries - with an economically fragile population and limited access to health services. Although treatable, the continued emergence of strains of Plasmodium resistant to available antimalarials is of concern. It is also equally a…
(Only some records are available in English at this moment)
Malaria is an ancient disease that has played a significant role in human history. In 2022 alone, 249 million cases were reported across 85 endemic countries, resulting in 608,000 deaths. The parasite's lifecycle is complex, and effectively treating and preventing malaria requires the development of strategies that target key stages of the lifecycle. To facilitate the study of transmissi…
Plasmodium vivax is the most common parasite species that causes human malaria outside Africa. This species is also the most endemic in Asia, Central and South America, and Oceania. Although Plasmodium falciparum is responsible for most deaths, P. vivax malaria is a significant cause of morbidity and mortality. Developing a protective vaccine will undoubtedly be an essential step toward m…
Malaria is a preventable, diagnosable and treatable disease. Yet, the disease causes thousands of deaths every year, and millions of people are still endangered. Almost all malaria cases worldwide are due to infection with Plasmodium vivax or P. falciparum. There is an urgent need to eliminate malaria, since drug resistance is reappearing, and there seems to be a general agreement that el…
Malaria is a preventable, diagnosable, and treatable disease. Nevertheless, it causes thousands of deaths every year, and millions of people are still endangered. There is an urgent need to eliminate malaria since drug resistance is reappearing. There is general agreement that elimination is not simply a matter of intensifying the use of available tools. New strategies, like transmission-…