Abstract
Glioblastoma multiforme (GBM) is the most common and lethal type of tumor of the central nervous system.. The glioblastoma stem-like cells (GSCs) represent the most undifferentiated and aggressive state of GBM malignant cells, being postulated to be responsible for reinitiating the tumorigenic process after the standard current therapy. In addition, the complex GBM intra-tumor heterogenei…