Abstract
The Acute Promyelocytic Leukemia is characterized mainly by chromosomal translocation t(15,17), that ends in fusion of PML (Promyelocytic Leukemic Protein) and RARa (Retinoic Acid Receptor) genes, generating the PML-RARa oncogene. This gene encodes a retinoic acid receptor mutant that contributes to leukemogenesis by interfering in the process of cell differentiation blocking the same at …