Abstract
Vogt and colleagues were among the first to show that insulin conferred cardioprotection in a porcine model of myocardial infarction via PI3K/Akt pathway, a finding that was further confirmed in ex vivo animal models of I/R. It is largely accepted that Akt activation by phosphorylation is strongly implicated in the cardioprotective response to I/R and that this signaling cascade leads to …