Abstract
Germline mutations in Shp2 gene cause Noonan Syndrome (NS) and LEOPARD syndrome (LS), genetic disorders that include heart defects and increased propensity to cancer,amoung its clinical manifestations. We showed earlier that Shp2 associates and negatively regulates FAK activity in cardiomyocytes, and directly interacts with FAK in vitro. We have seen that the modulation of FAK activity by…